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Cannabidiol: Promise and Pitfalls Over the past few years, increasing public and political pressure has supported legalization of medical marijuana. One of the main thrusts in this effort has Buy the best, full spectrum CBD oil made from Colorado hemp. Our CBD oil for sale comes with a 30-day money-back guarantee. Fast, easy ordering and delivery.

Cannabidiol: Promise and Pitfalls

Over the past few years, increasing public and political pressure has supported legalization of medical marijuana. One of the main thrusts in this effort has related to the treatment of refractory epilepsy—especially in children with Dravet syndrome—using cannabidiol (CBD). Despite initiatives in numerous states to at least legalize possession of CBD oil for treating epilepsy, little published evidence is available to prove or disprove the efficacy and safety of CBD in patients with epilepsy. This review highlights some of the basic science theory behind the use of CBD, summarizes published data on clinical use of CBD for epilepsy, and highlights issues related to the use of currently available CBD products.

Cannabidiol is the major nonpsychoactive component of Cannabis sativa. Over the centuries, a number of medicinal preparations derived from C. sativa have been employed for a variety of disorders, including gout, rheumatism, malaria, pain, and fever. These preparations were widely employed as analgesics by Western medical practitioners in the 19 th century (1). More recently, there is clinical evidence suggesting efficacy in HIV-associated neuropathic pain, as well as spasms associated with multiple sclerosis (1).

Basic Pharmacological Mechanisms

Cannabidiol pharmacological effects are mediated through G protein coupled receptors, cannabinoid type I (CB1) and cannabinoid type II (CB2), which are highly expressed in the hippocampus and other parts of the central nervous system (2). When activated, CB1 receptors inhibit synaptic transmission through action on voltage-gated calcium and potassium channels, which are known to modulate epileptiform and seizure activity (3). CB2 receptors are primarily expressed in the immune system and have limited expression in the central nervous system. The effects of CBD are CB2 receptor independent (3).

Studies have demonstrated that CBD has a low affinity for the CB1 receptors, but even at low concentrations, CBD decreases G-protein activity (3). CB1 receptors are expressed on many glutamatergic synapses that have been implicated in seizure threshold modulation. CBD may act at CB1 receptors to inhibit glutamate release (4). Studies have shown changes in the expression of CB1 receptors during epileptogenesis and after recurrent seizures (5). CB1 receptor expression is upregulated at GABAergic synapses and shown to be downregulated at glutamatergic synapses in epilepsy, contributing to lowering seizure thresholds.

Other targets for CBD include transient receptor potential (TRP) channels that are involved with the modulation of intracellular calcium (1, 6). Cannabinoids are highly lipophilic, allowing access to intracellular sites of action, resulting in increases in calcium in a variety of cell types including hippocampal neurons. CBD actions on calcium homeostasis may provide a basis for CBD neuroprotective properties.

Evidence in Animal Models

When administered alone, CBD is an effective anticonvulsant in maximal electrical shock (MES), magnesium-free, 4-aminopyridine, and audiogenic models (7, 8). Co-administration with AEDs leads to various effects; anticonvulsant effects of CBD are enhanced with phenytoin or phenobarbital but decreased with chlordiazepoxide, clonazepam, trimethadione, and ethosuximide. In a recent study using an acute pilocarpine model, although CBD administration reduced the number of animals displaying seizure activity, CBD did not appear to have any significant effect on the number of seizures per animal (7).

Clinical Evidence in Epilepsy

While animal experimental data clearly suggest a potential benefit, supportive clinical data are quite sparse. In a case-control study of 308 cases of new onset seizures, Brust and colleagues found that marijuana use was significantly less prevalent among men who had unprovoked seizures compared to case controls (9). This difference was not significant in women. The authors suggest a potential protective effect against seizures with marijuana use; however, this should be considered speculative.

A survey of patients seen in a tertiary epilepsy center found that 21% of patients admitted to using marijuana in the last year, and 24% of patients believed marijuana to be effective for their seizures (10). While interesting, this anecdotal observation does not rise to the level of evidence needed to evaluate a potential new therapeutic modality.

Gloss and Vickrey conducted a Cochrane systematic review of the use of CBD in the treatment of epilepsy (11). Their methodology included only those trials that were randomized and controlled and excluded case series, case reports, and expert opinion. They were able to identify only 4 randomized controlled studies reported in the literature, and they included a letter to the editor and an abstract. The total number of subjects enrolled in these studies was 48 (11–14). While only four studies and a letter to the editor were in the actual analysis, the authors included a complete reference listing of all articles reviewed for inclusion.

These reports suffered from a number of design flaws, including incomplete baseline quantification of baseline seizure frequency, indeterminate time periods for outcome determination and, in some cases, inadequate (or missing) statistical analysis—in general, a lack of sufficient detail to adequately evaluate and interpret the findings. Limitations aside, several studies did report that administration of adjunctive CBD did not result in meaningful changes in seizure frequency (11–13).

Cunha et al. reported a 2-phase pilot study of CBD versus placebo in normal volunteers and patients with refractory secondarily generalized epilepsy (14). In the first phase, 8 normal volunteers received CBD or placebo in a doubled-blind fashion, at a dose of 3 mg/kg for 30 days. The second phase was also double-blinded in 15 patients with epilepsy receiving 200 to 300 mg daily of CBD or placebo for 135 days. Patients continued baseline AED. All subjects tolerated CBD well, with no serious adverse events. Four of the epilepsy patients receiving CBD were “almost free of convulsive crisis” for the duration of the study. Three other patients receiving CBD had a partial reduction in seizures, and 1 subject had no response. Of the 7 patients receiving placebo, seizure frequency was unchanged in 6, and 1 had clear improvement in seizure control.

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Using rigorous review methodology, Gloss and Vickery conclude that based on the low quality of the reports available, there is insufficient data available to draw any conclusions regarding the efficacy and or long-term safety of CBD in treating epilepsy (11). From the data available, it does appear that daily doses of 200 to 300 mg were safe in this small group of patients for a short period of time (14).

Tolerability and Drug Interactions

CBD is well tolerated in humans with doses up to 600 mg not resulting in psychotic symptoms (15). In the few small placebo-controlled studies performed, no significant CNS effects were noted. Oral CBD undergoes extensive first-pass metabolism via CYP3A4, with a bioavailability of 6%. Following single doses in humans, the half-life of CBD when taken orally is about 1 to 2 days.1 In vitro studies have shown that CBD is a potent inhibitor of multiple CYP isozymes, including CYP 2C and CYP3A (16, 17). Whether these in vitro observations are relevant at plasma concentrations likely to be seen in patients is unclear. In addition, given its metabolism via CYP3A4, clinical trials of CBD in patients receiving enzyme-inducing AEDs, such as carbamazepine or phenytoin, will require detailed pharmacokinetic studies.

A number of difficulties exist in evaluating published data on CBD or marijuana use for epilepsy. The extremely limited published studies were small, poorly described, and not well designed. Contributing to the difficulty of interpreting published studies, CBD products are not produced under the guidance of good manufacturing practices (GMP) and are not subject to regulations governing labeling, purity, and reliability. In other words, currently, there is no guarantee of consistency between products, or even differing lots produced by the same manufacturer. Without independent testing (e.g. USP certification) of CBD products for content and purity, as well as bioavailability testing of specific products, uncertainty surrounds the use of available CBD products in routine clinical settings.

Conclusions

At this time, there does seem to be a growing body of basic pharmacologic data suggesting there may be a role for CBD, especially in the treatment of refractory epilepsy. However, given the lack of well-controlled trials, we must also ask if we are getting ahead of ourselves. Clearly, this is an emotionally and politically charged issue. If this were any other uninvestigated pharmaceutical compound, would we feel as compelled to make the agent widely available before statistically valid class 1 evidence was available for review? Until data from well-designed clinical trials are available and reliable, and standardized CBD products that are produced using GMP are available, caution must be exercised in any consideration of using CBD for the treatment of epilepsy. In the meantime, based upon promising preliminary data, further clinical research should be wholeheartedly pursued.

CBD Oil

High-quality CBD Oils are a quick and easy addition to your daily natural supplement regimen. Choose from an award-winning selection of full spectrum hemp extract flavors, including citrus, mint, natural, berry, and vanilla. Our CBD Oil is crafted from the finest organic industrial hemp plants while keeping the naturally occurring terpenes and other beneficial cannabinoids in place. Our highest quality oils are designed as high accessibility, full-spectrum blends that contain less than the required legal limit of 0.3% THC from hemp.

Product Details

Full spectrum hemp extract and CBD oils. 4 strengths, 5 flavors, 60 servings each and easy to follow instructions. We use organic flavoring and MCT oil to help increase the flavor profile as well as offer additional cognitive functionality. 300mg – 2400mg tincture bottles available.

Ingredients

Full Spectrum Hemp Extract (aerial parts) CBD, Fractionated Coconut Oil, Sunflower Seed Oil, Natural Flavors. *Contains Coconut.

Suggested Use

Take 1-2 servings a day or as needed. Can take day or night. Keep away from direct sunlight and store in room temperature. 1/2 Dropper or .5mL = 1 serving size.

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No need to break out the calculators and microscopes, we’ve got simple instructions on the bottle and measurement markers on our droppers.

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Let’s not waste time or money, shall we? You’re only getting top notch, Colorado-grown hemp here- you can check the third party lab results any time you want.

CBD OIL FOR ALL

You don’t have to be a hardcore athlete or a health guru to use CBD. If you have a body, you have an endocannabinoid system. That’s what CBD works with– not your particular personality or hobbies.

YOU’VE GOT OPTIONS

We have 5 flavors and 4 strengths for you to choose from, so you’re sure to find the combo you love.

It is the best! I’ be tried a few others, FAB is best.

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Definitely works, love this product. Please don’t hesitate, it works. Took care of the issues I bought it for. First thing I bought in a long time that actually lived up to and surpassed the claims.

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The FAB CBD oils we use have proven to be exceptionally good for various applications for both my wife and I.

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Thank you Jessica for sharing! We are so glad you found the mg of oil that works best for you. Thanks again!

I absolutely love the Citrus flavored oil but, once again, the purchase window defaulted to unflavored. but I didn’t catch the error in time to correct the order and I got 3 bottles of the unflavored. and I don’t like it. but it was my mistake so I’ll have to live with it. FAB was fabulous with correcting my error last time before it was shipped but this time I’ll use this as a teaching moment. check to make sure it’s the correct item before pushing “send”.

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We aim to please! Feel free to reach out to [email protected] with your order number and we’ll get back to you right away. Thanks for choosing us AGAIN! 🙂

Thank you so much Terry!

My wife likes this one. Does not really taste like Vanilla, more like coffee .

BUY THE BEST CBD OIL: WHY FAB STANDS ABOVE THE REST

FAB CBD has four strengths and five amazing, tasty flavors of organically grown hemp CBD oil. Each bottle has a year-long shelf life and is always made to order. In fact, when you buy CBD oil from FAB, you can count on receiving the best CBD oil around! CBD oil drops are best kept at room temperature away from excessive light, heat, or moisture.

Pure CBD oil may be able to provide:

  • Support for normal everyday stresses
  • Healthy recovery from exercise or daily activity
  • Support for a sense of calm that could ultimately boost overall focus

Because our organic CBD oil products are all natural and free of harmful pesticides, herbicides, and other dangerous chemicals and preservatives, they may visually vary slightly from batch to batch. Some CBD brands market hemp seed oil as synonymous with CBD oil, which is misleading. Our CBD tinctures always include whole plant extracts from the hemp plant, containing a unique blend of cannabinoids, terpenes, and other beneficial phytonutrients. As always, and per federal law, all of FAB CBD’s full spectrum CBD oil contain less than 0.3% THC.

Lastly, we share with you a word of caution: take care when using any CBD products as they may cause you to fail THC screenings. CBD can metabolize in such a way that it causes a false positive to be produced in a THC screening. It’s advised that you take any and all CBD products at your own risk.

CBD OIL THAT IS PACKED WITH AMAZING INGREDIENTS

FAB CBD Oil is crafted from the finest organically grown Colorado hemp and is extracted using the industry-preferred, clean Co2 extraction process. This means that there are no harmful solvents used, nor are their contaminants like heavy metals. All of FAB CBD’s full-spectrum CBD oils come in strengths of 300mg, 600mg, 1200mg, and 2400mg, and in flavors of citrus, mint, natural, berry, and vanilla.

All CBD Oil for sale on our website is created using non-gmo organically grown hemp extract, have a full-spectrum cannabinoid blend, flavoring from natural sources, contain beneficial terpenes and flavonoids, are packed with medium chain triglycerides (from MCT oil as the carrier oil), and contain less than 0.3% THC. Full spectrum oils are not THC-free, but contain levels so low that no psychoactive effects are possible. Certificates of analysis from third party lab testing reports are available to view on each product page

Lastly, we share with you a word of caution: take care when using any CBD products as they may cause you to fail THC screenings. CBD can metabolize in such a way that it causes a false positive to be produced in a THC screening. It’s advised that you take any and all CBD products at your own risk.

HOW TO PROPERLY USE FAB CBD FULL SPECTRUM OILS

To find the dose that is best for you, always dispense the oil using the dropper that comes with the bottle. Gently squeeze the rubber end of the dropper and release while still in the bottle. The dropper should then be about half full, which will indicate a “full dropper.” Please note that the oil will not fill the entire dropper for one dose. Drop the oil either directly into your mouth sublingually (or under the tongue).

A great rule of thumb when you first buy CBD oil is to begin low and go slow. So, if you’ve purchased a 600mg bottle of FAB CBD full spectrum oil, use a half a dropper full (about 5mg of CBD) once a day for about a week. After a week has elapsed, check in with yourself to see how you are feeling. If you feel the need to increase your dose, then try a half a dropper two times a day. This will equal about 10mg of CBD oil a day. Again, stay at this dose for another week before checking in with yourself. Keep using this method until you find the dose that best suits your needs.

  • Do not touch the dropper to your mouth and/or tongue so that you will be able to preserve the quality of your CBD hemp extract.
  • The 30ml CBD oil bottle contains 30-1ml servings or 60-.5ml servings. Your reaction, as well as doctor guidance, will help you determine the proper serving size for yourself.
  • The dropper in all of FAB CBD’s 30ml bottles can hold 1ml of CBD oil tincture.
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POTENCY

When you decide to purchase CBD oil online and you are trying to figure out which type and potency is right for you, it’s best to start small and gradually increase your dose until you reach your desired result. You might not even need a full CBD serving. You also might not need the strongest CBD oil for sale either. While we have CBD isolate and broad-spectrum CBD products, our oils are all full-spectrum. You should, of course, always consult with your doctor or medical specialist just the same as you would with any daily dietary supplement addition.

FAB CBD offers many strengths of CBD oil potency, as well as an amazing array of natural flavors. You may need to try different potencies to find the best CBD serving size for you (with your doctor’s guidance, of course). Keep in mind that everyone is different, and while some may only need a little bit of oil, others may need more to achieve their desired results. Once you have figured out your potency, then you’ll be able to always find the best CBD products for yourself.

FAB CBD Oil tinctures, topicals, and chews are non-psychoactive as they only contain less than 0.3% THC. We advise that you use caution when using any full-spectrum CBD products, as they may cause you to fail a THC test/screening in the lab. All types of CBD also have the ability to metabolize in such a way that it can cause false positive test results to appear on THC screenings/tests. Remember, while the USDA has implemented the 2018 Farm Bill, CBD oils are still not evaluated by the Food and Drug Administration (FDA). It is for all of these reasons that you should take any and all CBD oil and CBD products at your own risk.

CBD OIL FAQ

Why Choose FAB CBD Oil?

All of the FAB CBD products for sale are a cut above the rest because we’re thinking about our customers the whole way through. From the pristine organic hemp farms in Colorado, USA, to the best CBD product formulations, to the rigorous third party CBD testing, we are maintaining quality from start to finish. It’s important to us that you feel comfortable with CBD, whether you’re using CBD oil, CBD gummies, or topical CBD products. To that end, we offer spectacular customer service that surpasses the rest in the CBD industry.

What Else is in FAB CBD Oil Besides CBD?

Our CBD oil contains only naturally occurring cannabinoids extracted from pure USA hemp, natural flavors, and MCT (medium chain triglycerides) like coconut oil so that you can easily take your oil in a dropper and your body will absorb it easily and efficiently.

How Much CBD Oil Should I Take?

The serving suggestion on our bottles is to take 1/2 dropper as a serving size. It’s suggested to new users that they try this daily for a week and then if you aren’t feeling any effect, take either a full dropper daily or 1/2 dropper twice per day. Every time you increase your amount, give your body a few days to acclimate and pay attention to what you feel. That will get you to your sweet spot.

Why Buy Full Spectrum CBD Oil?

This is a personal preference. Some customers like full spectrum oils because they contain the full profile of cannabinoid content. Others like broad spectrum oils because the THC has been specifically taken out. THC is the cannabinoid that can cause a feeling of euphoria or “high.” This effect only happens when ingested in large amounts, and hemp plants (unlike marijuana plants) have been bred to possess such miniscule quantities of THC that they cannot induce any psychoactive effects when ingested. However, those who are still nervous about THC may opt for braod spectrum oils.

What Potency of CBD Oil is Most Effective?

CBD dosage is not one-size-fits-all. Everybody is different, and taking too much CBD can be just as ineffective as taking too little. We recommend starting with a dose of 10-20mg once a day for at least 5-7 days before changing your dosage. Try to take your Fab CBD Oil at about the same time every day. With our CBD oil products you can easily control how much you take because you’re using a dropper with convenient measurement markers on the side.

What Flavors Are Available?

Our full spectrum CBD oils come in five flavors and four strengths: Citrus, Vanilla, Berry, Mint, and Natural flavors in 300mg, 600mg, 1200mg, and 2400mg strengths.

Can You Take CBD Oil on an Airplane?

Within the US, you can fly with CBD oil as long as it’s hemp-derived and contains less than 0.3% THC (which is the norm for all reputable CBD brands). As always, you must adhere to TSA guidelines regarding liquids of any type, so you’ll have to be sure your CBD oil is under 3 fl oz (most bottles are only 1 fl oz).

When Will My Order Arrive?

Shipping typically takes 3-7 business days to arrive. However, since COVID-19 we are seeing some longer delivery times in certain areas or during busier times of the year. Shipping may take up to 10 business days. If for any reason your order doesn’t arrive in that timeframe please email [email protected] and we’ll be happy to help!

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