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Monk Wu Neng couldn t help but smile and said, Yes! My great-uncle and great-grandfather is a monk! Since no one cbd gummies for anxiety in my father s generation has become a monk, when it comes to my grandson s generation, someone must be filial, so I became this monk. Hello! Who are you catching! Don t you have eyes? This is our own! The swordsman was performing. This is too fast! It s too late for the President to send the imperial decree urgently for 800 miles! Unless it s a flying pigeon, it s already prepared. Looking at Zhang Fu, I don t cbd products understand, because Zhang Fu doesn t need to cbd oil users group show him the content of the imperial edict at all. cbd oil users group

cbd gummies legal nj The ser watched, his eyes seemed to read everything, How bold!! Do you know that my Daming law prohibits officials from doing business? You are actually a relative and run a ranch cbd oil users group privately! What crime do you have to cbd oil users group do! No one was at this moment. Now I want some money, what s wrong? Shouldn t it? Do you know who I am? Who are my uncle and grandfather. Ah, you made the big man cry, so sad, you are necrotic! Therefore, the side of Dateng Gorge is temporarily safe and cbd oil users group given time.

He said, Let s go! Let s go! The warrior was stunned, aren t you here to persuade An Ji? Why are you calling away? It s not done yet. Lan Dayong walked cbd oil users group upside down, cbd oil users group watching this scene, he gritted his teeth, he couldn t help it! This is real money.

The soldiers also laughed and said, That s right! Don t look at him as a hero, but he can t be a coward in the best cbd gummies end! You must know that there is someone on Mr Shen. Occasionally there are fish that slip cbd oil users group through the net, and the number of deaths must be the majority. Others can t see it, but they are laughing, so bad! Even a vicious dog wants to bully him! He is so herbal just cbd gummies miserable. When Xixi heard this, her eyes lit up! Wonderful! Xixi laughed and said, As expected of my son! Sure enough, I thought of going with my father! Good! You cbd oil users group can do it immediately.

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Isn t there some Jianwen Yu Party for our use? So let them out! Just let the old man know and suggest a reconciliation! This is impossible. As they were talking, a huge head poked out from the bamboo forest, It was a tiger s head. When Ji Gang saw this, he couldn t help but smile, He knew that this was something he didn t take seriously, and that he knew that he could tame beasts, so he specially gave him a small beast, and in the future he would be like having a bodyguard by his side. If there were not enough people, new cbd gummies You can also come back and ask for reinforcements. If not, others will only think that he is justcbd cbd gummies an old man! No wonder he was a online buy your cbd store monk.

Zhang Hui s eyes lit up, he wanted to stand up, but he said no, But faster: I said it! 8 gummies Who am I? The United States values me! When I am in trouble, the officers and troops will come desperately and quickly! How is it now? Am I right. Naturally understand, don t cbd oil users group push the opponent too hard, otherwise he will have to suffer if he fights to the death! best cbd gummies for adhd and odd in kids This is something that cannot be done. As the president s slave, if he really wanted his head, he had no choice but to die obediently.

He strode away, but Ma Jing came over with a smile, and she was about to shake hands. They all stared straight at it, It can be said that the status among the cbd near me Jiaozhi people has been greatly improved.

Yes! Luo Qi s foot was swollen from cbd oil users group being stepped on, It was very painful, but how could it compare to the pain of being slapped in the face. If this is the case, it is also reasonable, Being stabbed, the Qin cbd gummies family is suspected, and they are under great pressure. Wow, many people called out! This is a big tiger! Cannibal! How can you tame cbd oil users group like a cat. cbd oil users group Yes! At that time, Mu Sheng can say that he died unexpectedly in the chaos, yes. 8 gummies

Li Qianhu summoned him, and Li Qianhu went straight to the topic: You said some time ago that your relatives will serve the cbd ed gummies Ming Dynasty and help the elephant taming guards. Don t you mean to push your daughter to you? How could anyone rush to give their daughter to others as a slave and a maid! What s even more irritating is that it is a daughter who is like a fairy. The two knelt down on the ground, motionless, their hearts were up and down. At cbd oil users group the same time, the fire guns are in their respective cbd oil users group positions, and what is even more exaggerated is that the marshal actually pulled a cannon. Ah! No! The big thing is bad! Xixi stood up with a swoosh and said, This is not Yuan Cheng s troops! This is the enemy! We have fallen for the enemy s trick! Quick! Quickly close it.

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Zheng He looked very frustrated and asked, Are all the things you showed me true. If you start a sword cbd oil users group fight because of this, the unreasonable side will always be your Ming Kingdom! How will the countries cbd gummy candy view your Ming Kingdom! In the future, herb gummies no matter who it is, it will only say that your Ming Kingdom only knows how to bully the weak. What kind of leader are you! Now they don t want to be tortured anymore! They are going to commit the following crimes! They are going out cbd gummies say take one can i take two of the sea of misery. Ying Wen laughed, he didn t fight so much anymore, he knew that he could do this, the promise he could get, that s enough. Wu Yongbao and others knew that the two elephants they brought were the most elite elephants in the Annan Kingdom! Don t be afraid of fighting. What are you playing? How can you not count me! I want to play too! A voice sounded.

If it goes further, it will be the territory of the rebels, which will be very dangerous. Luo benefits of cbd Qi said: Sergeant Long, the elephant taming guards have cattle, one is for the soldiers to settle the fields, and the other is that there is no cbd oil gummies supply of cattle for the people, so cbd oil users group for agricultural needs, we need the cattle raised by the elephant cbd oil users group taming guards. The dog-legs royal cbd cbd oil users group are screaming in pain, how majestic they used to be! Have you ever suffered cbd gummies supplements such a loss, you can t let it go! Not even a cat can cbd oil users group be spared. He is very resentful! Xiaoqi pointed and said, Look! The people you protect, what happens to them when you have an accident? They don t even dare to look at you! They are waiting for you to die! Boy, you regret it.

I want to continue to provoke him: Yo! cbd oil users group Haven t you seen someone who is very arrogant? Then you have seen it now! I just want to show you how arrogant a person can be! cbd oil users group How is cbd oil users group it? Do you think it s amazing. No! No! How could it be him! He came from a hero! Could it be him? Xiaoqi looked at me with pride, very arrogant, what can you do to me. The first warrior walked qualified thc gummies upside down, which is really a strange story, and a lot of people gathered to see what happened. There was an old man cbd oil users group reduce anxiety global green cbd gummies who thought he knew it, and said, Long Qingtian, you have done your cbd for anxiety best! Our people in Yiliang County will be grateful to you! At least Long Qingtian cbd oil users group has done what his predecessors could not do! It s not something everyone can do.

Cbd Oil Users Group Just bring these two, and he can make things clear! It is cbd oil users group very important that the old mountain pig can play the role of pure cbd oil an old horse knows the way. One of the pedestrians cried: It s so unreasonable! Look! His feet are full of Li Guo! At least he weighs a lot of pounds! How many girls throw Li Guo by his side! Why am I the only one? Li Guo didn t throw it either! Woohoo! So sad. When he saw it, natures remedy cbd gummies bears he couldn t help laughing and said, Okay! Did you see it? It s good! This kid didn t let me down! He s a good player in the military. Exaggeratedly shouted: Aah! It s not good! Someone is going to kill someone.

Can he still hang out before? Maybe he ate too much mutton, so today s report. Finally, the day came, and all kinds of Taoists and priests came to show their magical powers. The merchant was so frightened that he lost his soul, so let him cut it with a knife? Can t even pull out the knife. Suddenly, the reputation has become very high, Su Zhen s star eyes sparkled, but what made her very upset was that she heard some girls words: I wonder if Long Qingtian is married? Even if cbd oil users group Long Qingtian is married, it is a blessing to be his concubine. Brother Long, let s go and see it together! Qin Fangfang pinched Li Kai, and with a wink, Li Kai understood and said, Long Ye, I want to propose a marriage at Fangfang s house.

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He justcbd cbd gummies said, You don t have to sell the fields, how much cash do you have. Looking at it, Mu Sheng couldn t wait, and said, Yeah! I ll get on the sill first and rest early! I cbd oil users group m cbd pills tired, the sill should rest. Yang Changchun nodded and made a humming mocking sound, The mosquitoes were all focused on Yang Changchun. Look at them, Cbd Oil Users Group without saying a word, let someone send money first, Issued cbd oil users group in copper coins. He smiled and said, Aah! Someone just said that I m not! How is it? You want cbd oil users group to take me away? How is the situation now. When I saw this servant, cbd oil users group I felt unusual! Is this the next person? If you are a servant, cbd oil users group you can t look around when helping your master down, especially if you are looking at other people s weapons! This man has a problem. He pointed to the map and said, Now the Hu army is gathered at Xianziguan, which is their last stronghold! Originally, Annan s territory was not large, and there was not much strategic cbd oil users group depth. Nodding one after another, he said, Okay! You should have a good rest! Please go all the way.

I m not wrong! Who dares to hit me! Lan Dayong shouted, he looked at it proudly, and said, I called! How are you? I will call again! If you don t say it three times, why not say it a hundred times? Who else cbd oil users group can get me. I heard that the envoys of Annan were showing off cbd pills their might in cbd oil users group Nanning, and now that they came to the Elephant Taming Guard, they should really suffer! Let them know how great Daming is. Just let the wolves bow their heads? This is impossible! Have your own idea! He is not afraid of evil thieves like Jin Yiwei. And once he has made great achievements, he will meet Zhu Di in the future. Emperor Yongle looked at the prince and said, Boss, what I just said, you tasted unusual.

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Because the bald eagle has affected the development of tile spurs, this stumbling block must be removed. Looking at the damaged helmet, he said loudly: Brother, why is your marksmanship so bad? As a man, cbd oil users group it s not okay to have bad marksmanship! I started playing with guns when I was one year old, why don t you just be a good guest here? I will teach you how to play with a gun! How is it. At night, wild boars entered the camp, followed by the sound of tigers roaring one after another. No, the family members of the two rushed to the other side and said together, We don t know them! They have nothing to do with us! It has nothing to do with us. When the others heard it, they nodded again and again, Indeed, the artillery can t hit so far. The purpose of training elephants cbd oil users group in Annan is cbd oil users group to fight, and the elephant taming guard is used for ceremonies first, and the second cbd oil users group is for fighting.

This was a plan, He ordered a part of the attack to attract Hu Jun s forces to the east, and Hu Jun would be vulnerable. It can be seen that these assassins want to die, this is impossible! I used to laugh at assassins before, and I regretted that my bowels were green! Cheating! How can you cheat like this. cbd oil users group I remind you, a handkerchief! When you escaped from Dateng Gorge to Baohua Mountain, someone saw that you were pitiful and gave you a handkerchief. It s so fresh! These rich people have gained knowledge, and the climax is coming! The wealth of the rich also has to be drawn out of the purse. is watching! Yes! Know that as long as you have the ability to last for a while, that s fine! At the same time, he also glanced at Ji Gang, and his heart was full of complexity. The purpose of Luo Guangmei s ear piercing tour has been achieved, When he came to the secret room, he revealed his plan and everything. If he hadn t had this kind of animal taming skills and various cultivation methods, it would have been almost impossible. It was so beautiful and amazing! That s why cbd oil users group I sent out the emotion of marry cost of keoni cbd gummies this woman. The people cbd oil users group who cbd oil users group cbd oil users group were pointed all nodded, they knew what to do, Raising his arms, he made a generous speech: Brothers! The first credit belongs to us! As long as future generations think of the Battle of Peaceful Jiaozhi, they will give a thumbs up and praise us! Each of us is a hero.

He said, If the pig understands it and comes up sale pills cbd near me to seek revenge on you, you can t ask others to help you! You have to settle your grievances yourself. mall gummies price You have to persevere! Because it s about Daming s face! Even if he fails, he is buried in the mouth of all beasts, and cbd oil users group he has to fight. Sitting together with Mu Sheng, the two of them were really distracted from this moment. just cbd gummies 1000mg dosage The Sixth King waved his hand, all he wanted was this sentence! They are now setting up an ambush by the sea, waiting for the cbd oil users group Japanese pirates to come. Wu Yongbao was stunned for a moment, he didn t understand, Wu Fulu whispered in Wu Yongbao s ear, Wu Yongbao sneered, and said, This is your Ming Dynasty and our Annan Kingdom for diplomatic relations! Are you causing war between the two countries just for one woman? Ah.

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Because he heard it from the cbd oil users group bird s voice, it was a notification: Master! Great things can be done! Just a moment. With these two big animals, it is very difficult to hold them! Ah Liss just wanted to cbd oil users group retreat now, to retreat to the back, he felt great danger. It gummies products was a hearty laugh! The whole courtroom was full of cbd capsules laughter! Jazz couldn t help but glanced at him, wondering what this smile meant. Repeat: I ll go to your village with you guys to get the bottom of it. Li Qianhu did not dare to neglect, he ordered the merchants to select a group of elite people to follow. The diners at this cbd gummies table were so frightened that they immediately left the cbd oil users group table and bowed to each other to plead guilty. One thing can be known, Ma Jing is a bad visitor! He must have a plan, but he can t take it lightly. cbd oil users group Some toasts also shrank their necks, for fear that the cbd gummies gaithersburg axe and the big daily cbd gummies knife would fall and take their lives. Of course, he kept cbd oil users group saying good things on the side, He smiled and asked, Lisheng, do you think I should make a will? Who should I make emperor. He didn t come here for nothing, he wanted to have a good relationship with the people of Dacheng Village. Zhang Fu cbd oil users group came down with a smile, and he held on to his hand and said very affectionately, Come on! Let s go drinking with Uncle Zhang.

He said: Ji Gang! I hope you didn t commit a major crime! In this case, you can avoid death! If you find out that you have committed a major crime! Then you are dead. Huang Baihu justcbd cbd gummies can recognize at a glance that the token is real, how can it be fake. Ying Xian came out and pointed at Xue Yan, scolding: The emperor treats you well and trusts you! But how did you do it? If it weren t for what you did, we would have won the battle of Jingnan, how could we have won? Let the King of Thieves succeed.

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In fact, all of them called together: Make merit and career! Defeating Beiyuan is far more credited than defeating Japanese pirates! They are now looking for a marquis from thousands of miles. Ji Gang had an ominous premonition, but when someone flipped it, cbd oil users group there was information in front and blank in the back. Once he threatens his dragon chair, he will kill people mercilessly! Because Zhu Yunwen s son is still imprisoned in Fengyang. Cheng Jin is not convinced! He shouted: You does work cannabis gummies dare not do anything to me! Humph! I am a relative of cbd oil users group Duke cbd oil users group Qian! You are not good to me, Duke Qian will not let you go! If you are sensible, let me go. You are the pride of our elephant guards! We are proud of you! The Confucian scholar, who just said cbd oil users group reduce anxiety global green cbd gummies that he should die to thank the cbd drinks world, bumped his head and said regretfully, How can I call a hero a person amazon green lobster cbd gummies who brings disaster to the country and the people? My eyes are blind! I almost defiled the great hero. As long as someone becomes a general, they can assist Jianwen in the future. Therefore, the elephants of cbd oil users group the elephant taming guards are arrogant, and the others are experts, and they cannot be compared. When other people saw it, they were all scared, Who would dare to say no? Watch out for an arrow. effective gummies for sleep

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If the imperial court believes that, and misunderstands that Lord Long has evil intentions, then it is extremely bad! If you revolt, all the nine clans will be punished. The city of Nanjing was broken, and Xue Yan became one of the civil servants who greeted Zhu Di.

Needless to say, naturally began to pack up, At night, as expected, a group of people came, and their purpose was obvious, and they wanted to set fire here. A Japanese pirate s eyes flashed with strange light: It s so flat here! All the way to the plain, we can kill it directly! There is a prosperous town not far ahead! We shark tank cbd gummies for tinnitus episode can get a lot of money by killing the town. The feces of the swordsman, he really wanted to report, and his crime was confirmed, which was the last thing he wanted to see. The Li brothers had already tried their best to stop the Ming army, but the Ming army was too strong cbd oil users group for online thc gummies them to stop.

This move has a great educational significance for the defenders in the city. Another Ming army shouted: Hold on! We are here to support you! When the marshal looked from afar, he was shocked! Both sides of the Ming Army are here! How could it come so quickly. As soon as these words came out, people were laughing and talking big words. As soon as the plague of locusts appears, the nomads on the grasslands will begin to loot the farming people, because they want cbd oil users group pain relief to transfer the loss and pain. When the others heard it, they all laughed, nodded again and again, and praised with allergy to cbd oil thumbs up! smart. Then a dog ran over cbd oil users group quickly, with something in its mouth, and took what was in the dog s mouth. Even if you dodge an arrow, the knife will split cbd gummies free trial uk your head in two! gummy bears what is cbd It is inevitable.

Another person spit out a mouthful of water and said, A beggar who has offended the rich and powerful son, and wants to eat swan meat for the official lady, deserves it. Xue Yan stood up, cbd oil users group He faced Hu Jun and shouted loudly: You dare to ambush my Da Ming soldiers! You should bear my Da Ming s thunder and anger. Look again, yes! Moving around manually is telling people that it is under his command that the group of dogs will attack.

cbd oil 8 gummies appetite stimulant With this heavy blow, I want to get the first move! Knock it down! No hiding! He stood upright, Bah! The hand shield in his hand was pushed up! This is a bodyguard who has the power to fall. What s even more amazing is that as soon as the boars bypassed the antlers, they immediately converged, forming a formation. cbd gummies for pain The soldiers did not dare to move, they immediately retreated to the back, waiting to speak again. Luo Guangmei said, Isn t it true? We originally wanted to maintain the friendship of the landlords, and to have a good relationship with each other! With such a mess, everything is over! The worse things get worse, everything is to blame. .

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CBD statistics 2022

22% of people say they don’t trust CBD, but 68% of CBD users find it effective. Get your CBD stats straight before you try this natural remedy.

There’s no getting around it: CBD is officially everywhere . Its popularity has skyrocketed. What started as a niche alternative health treatment has become a nationwide craze. And it doesn’t just show up as oils and tinctures anymore. There is whole array of curious CBD products, including lattes, makeup, bedsheets, bath bombs, and even dog treats.

But is CBD a wonder drug, or just another health fad? There’s no shortage of opinions out there, but we can discern a lot from CBD statistics. We’ve compiled reliable research and conducted a CBD survey to put the prevalence of CBD use and its potential health benefits into perspective.

What is CBD?

When some people hear “CBD,” their minds immediately jump to marijuana. And while there is a connection, it’s not as close as one might think. Since recreational and medical cannabis is available in several states now, it’s important to note the differences. CBD is primarily a hemp derivative, which is like a cousin to marijuana, but not the same plant.

Let’s take a step back. Both hemp and marijuana fall into the cannabis genus. Cannabis plants contain two naturally-occurring compounds: cannabidiol (CBD) and tetrahydrocannabinol (THC). CBD and THC are both cannabinoids but have different effects on the body. Most prominently, THC has psychoactive effects and CBD doesn’t, which is why CBD doesn’t make you feel high.

Marijuana and hemp each contain both compounds but in different ratios. Hemp has much lower levels of THC and larger amounts of CBD, which is why it’s often used for CBD products. Marijuana, on the other hand, has significantly more THC.

CBD uses

People use CBD for almost everything. Name a medical condition and there’s likely someone out there treating it with CBD or other cannabis products. But when someone claims that CBD cured their migraines or skin rash, take it with a grain of salt. Because the CBD industry is so new, there simply hasn’t been enough research to fully understand its effects yet.

While it shows plenty of promise in treating various conditions, “it is not a one-size-fits-all [remedy] to treat specific conditions or symptoms of those conditions for every individual,” says Manisha Singal, MD, the founder of Aethera Beauty . “Research on the benefits and action of CBD in topical formulations as well as ingestible forms is ongoing. That experimentation is in its preliminary stages and there is a long way to go. The medical potential for CBD and other cannabinoids is undeniable, but medical research takes time and careful analysis.”

That said, it has shown efficacy in treating chronic pain and anxiety (two of its most common uses), as well as insomnia and arthritis. And the only FDA-approved medication that contains cannabidiol so far is Epidiolex , which treats childhood seizures associated with Dravet Syndrome or Lennox-Gastaut Syndrome in patients two years of age and older.

How common is CBD use?

  • 33% of American adults have used CBD once or more. (SingleCare, 2020)
  • 64% of Americans are familiar with CBD and/or CBD products. (Gallup, 2019)
  • An estimated 64 million Americans have tried CBD in the last 24 months. (Consumer Reports, 2019)
  • Of those who use CBD, 22% said it helped them supplement or replace prescription or over-the-counter drugs. (Consumer Reports, 2019)

CBD statistics in America

  • Hemp-derived CBD products are legal in all 50 states, as long as they contain no more than 0.3% THC. (Food and Drug Administration, 2020)
  • In overall cannabis sales, Colorado tops the list, having sold over $1 billion since 2014. (CNN, 2019)
  • The top states for CBD sales in 2019 are California ($730 million), Florida ($291 million), and New York ($215 million). (Statista, 2019)
  • Of the Americans who use CBD, the most common uses are for pain relief (64%), anxiety (49%), and insomnia (42%). (SingleCare, 2020)
  • CBD web searches increased by 125.9% from 2016 to 2017 and 160.4% from 2017 to 2018. ( JAMA Network , 2019)
  • United States hemp farmland increased from 25,713 acres in 2017 to 78,176 acres in 2018. (Food Business News, 2019)

CBD statistics by age

CBD user demographics skew young. Of all age groups, Americans age 18-29 are most likely to use CBD consistently, and its popularity decreases with age. (Gallup, 2019):

  • 20% of people ages 18-29 use CBD
  • 16% of people ages 30-49 use CBD
  • 11% of people ages 50-64 use CBD
  • 8% of people age 65 and older use CBD

And the numbers nearly double for adults who have tried it once or more. According to a 2019 Consumer Reports CBD survey:

  • 40% of people ages 18-29 have tried CBD
  • 32% of people ages 30-44 have tried CBD
  • 23% of people ages 45-59 have tried CBD
  • 15% of people 60 and older have tried CBD

CBD statistics by method

According to our SingleCare survey, nearly half of CBD users prefer oils/tinctures, lotions/balms, and gummies. But there’s a growing market for CBD edibles.

  • 18% are interested in capsules/tablets
  • 18% are interested in topical sprays
  • 17% are interested in CBD-infused food, such as chocolate
  • 13% are interested in vaping products
  • 12% are interested in soap
  • 11% are interested in non-alcoholic, CBD-infused drinks
  • 9% are interested in CBD bath bombs and salts
  • 8% are interested in skincare products
  • 8% are interested in patches
  • 1% are interested in other CBD products

When it comes to where CBD users get their products, a 2019 Consumer Reports study says:

  • 40% purchase CBD from a dispensary
  • 34% purchase CBD from a retail store
  • 27% purchase CBD from an online retailer
  • 12% purchase CBD from another source

CBD and overall health

CBD enthusiasts will tell you that it changed their lives, citing all sorts of positive effects. Skeptics will tell you that it’s all hype and has no actual benefits. The truth falls somewhere in between. Our survey found that 32% of people who’ve used CBD did not find it effective. While there hasn’t been extensive research on its effects, it shows promise as an anti-inflammatory , anti-anxiety treatment, as well as a sleep aid . And this can give us some insight into CBD’s appeal as a new addition to holistic wellness routines.

People tout CBD as a miracle treatment for heart disease, cancer, autoimmune diseases, Alzheimer’s, acne, and much more. Researchers haven’t found substantial evidence that it can effectively treat any of these conditions, but we also know that inflammation and stress can be contributing factors to these conditions. So, there may be some truth to the claims that CBD is beneficial to everyday health. Whether it’s in a morning smoothie, part of a skincare routine, or something else entirely, regular CBD use can potentially be beneficial for some people, although it comes with risks too.

Recreational vs. medical cannabis use

Recreational cannabis use isn’t quite the same as medical use. CBD oil and other products intended for medical use typically come in smaller doses and aren’t full-spectrum CBD (or “whole plant” CBD), which contains THC as well.

“CBD can have varying strengths depending on if it is used in isolation or if used in conjunction with THC for entourage effects,” says Dr. Singal. And some people want these compound effects. However, there are a ton of CBD producers and retailers out there, and not all of them are reliable. Although 47% of the Americans that we surveyed think the government regulates CBD, it does not.

A recent study by Penn Medicine revealed that almost 70% of cannabidiol products sold online are mislabeled. So, products from online retailers that haven’t been properly vetted could contain higher levels of THC or other compounds. Our survey found that 22% of people won’t try CBD because they don’t trust the product or manufacturer.

CBD side effects

Like other medications, CBD can have side effects, too. In one study , one-third of CBD users reported a non-serious side effect, including dry mouth, euphoria, hunger, irritated eyes, and/or fatigue. And according to Michael Hall, MD, the founder of the Hall Longevity Clinic , the spectrum of side effects is even broader.

“CBD contains multiple oil-based terpenes, which can excite the immune system,” says Dr. Hall. “The most common side effects associated with CBD-based products include sleepiness, sedation, and lethargy; elevated liver enzymes; decreased appetite; diarrhea; rash; fatigue, malaise, and weakness; insomnia, and possible interaction with some prescription medications.”

Typically, these effects aren’t dire, but they can be inconvenient and disruptive to a person’s everyday routine.

As far as drug interactions go, there hasn’t been a ton of research and testing, so it’s hard to say. CBD can potentially interfere with tacrolimus , an immunosuppressive medication. Because there are a lot of unknowns, anyone looking to supplement their current medications with CBD should consult a healthcare provider first.

The cost of CBD

America’s CBD market has a near-vertical trajectory. With the legalization of recreational and medical marijuana in numerous states, an increasing number of people are looking into the benefits of cannabis, and CBD sales reflect that interest.

  • The United States CBD market value was just over $4 billion in 2019 and may top $25 billion by 2025. (Brightfield Group, 2019)
  • The cannabis- and hemp-derived CBD market may see a compound annual growth rate (CAGR) of 49% by 2024. (BDSA, 2019)
  • 44% of regular CBD users spend $20-$80 per month on CBD products. 13% spend more than $160 per month. (Brightfield Group, 2019)

CBD law and restrictions

Here’s the big question: is CBD legal or not? The laws around cannabis are frequently changing and vary from state to state. CBD derived from hemp is legal, as long as it meets certain requirements. The Agriculture Improvement Act of 2018 (AKA the 2018 Farm Bill) allowed for the production and marketing of hemp-derived CBD products without federal regulation as long as they contain no more than 0.3% THC. But these products should not be labeled or marketed as medications. The FDA has only approved one CBD-based drug (Epidiolex), so the sale of other CBD products as drugs for the treatment of specific medical conditions is not yet legal.

Additionally, the FDA has not approved products that contain cannabis or cannabis-derived compounds for medical use. In fact, at the federal level, all marijuana is illegal (medical or otherwise). It’s still classified as a Schedule I substance (along with heroin and LSD) by the DEA under the Controlled Substances Act . However, 33 states have legalized it for medical purposes, and 11 of those have approved recreational use for adults 21 and older. Technically, federal law supersedes state law, but the federal government has not chosen to prosecute businesses and/or individuals selling or using cannabis in states where it’s been legalized.

CBD questions and answers

How many people know what CBD is?

In a recent Gallup poll, 64% of U.S. adults said that they were familiar with CBD and/or CBD products. In a 2020 SingleCare survey, we found that one-third of Americans have used CBD.

Why do people use CBD?

People claim that CBD can treat everything from acne to cancer. But the most common uses are for pain, inflammation, anxiety, and insomnia.

What age group uses CBD the most?

CBD use is most common in populations ages 18-34, according to a recent SingleCare survey.

How much money is spent on CBD?

The CBD market exceeded $4 billion in 2019, according to a study by the Brightfield Group, and they expect the industry to top $25 billion by 2025.

How many people have died from ingesting CBD oil?

CBD oil consumption has not been directly linked to any deaths. One of the most popular CBD products is vape cartridges, however, and the FDA has linked vaping to certain lung injuries and death .

CBD: A User’s Guide

CBD is seemingly everywhere and in everything, from CBD-infused creams to CBD-infused oils, tinctures, gummies, juices, and lollipops. But does it work, and is it safe? We’ve got your questions covered.

I n case you haven’t heard, CBD is a cure for whatever ails you, from insomnia and inflammation to pandemic angst. Or at least that’s what retailers, supermarkets, mini-marts, beauty stores, and coffee and smoothie shops across America would have you believe. There are CBD-infused creams. CBD-infused oils. CBD-infused tinctures, gummies, juices, lollipops, lattes, nutritional supplements, and even a CBD oil–infused pillow! What’s next, CBD-infused tampons? (Actually, that already exists. Really.)

According to the Brightfield Group, a market research firm, CBD sales were estimated to exceed $4 billion at the end of 2021, and by 2025, the industry’s total market value could reach a whopping $16 billion.

Put that in your pipe and smoke it.

But does CBD work?

That’s a question worthy of a Talmudic scholar, because the CBD world is complicated.

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Some believe that it may have an important role to play in certain health outcomes.

Raphael Mechoulam, PhD, a professor of medicinal chemistry at Hebrew University in Jerusalem, Israel, has been studying the health benefits of cannabis and CBD since the early 1960s. Long considered the grandfather of cannabis research, Dr. Mechoulam and his team developed a process for synthesizing certain acids found in the cannabis plant. These acids — otherwise known as cannabidiolic acid (CBDA), and a methylated version of CBDA (CBDA-ME) — have been since studied for a variety of purposes, and might ultimately be used to develop new drugs for everything from arthritis and anxiety to inflammatory bowel disease and psoriasis.

Others believe CBD is unproven and risky.

The U.S. Food and Drug Administration (FDA) continues to investigate its potential harms, noting that while it recognizes the potential opportunity that cannabis-derived compounds (like CBD) can offer, it remains concerned about CBD products being marketed as supplements. (According to the FDA, THC and CBD products do not fit the definition of a dietary supplement.)

“FDA is aware that some companies are marketing products containing cannabis and cannabis-derived compounds in ways that violate the Federal Food, Drug, and Cosmetic Act (FD&C Act), and that may put the health and safety of consumers at risk,” the Agency wrote in its 2021 update, noting that it’s illegal to market CBD by adding it to a food or labeling it as a dietary supplement.

Among a number of problems with CBD, the FDA says, is that it can cause liver damage and diarrhea, it may impact the metabolism of other drugs, and it may cause male reproductive toxicity in humans, as has been found in animal studies.

Still, many consumers continue to believe CBD’s potential benefits. A report (PDF), also from the Brightfield Group, that analyzed 2,400 members of an online community of medical cannabis users found that 59 percent of CBD users say they use it for insomnia and 66 percent for anxiety, while 44 percent have taken it for depression and 49 percent for joint pain and inflammation.

With so much CBD noise out there, we’re feeling a little overwhelmed and confused about CBD. We want to know the real deal. For starters, is CBD the same as cannabis? Should we spend our hard-earned money on the stuff, or is it a scam? Is there any science to back up the claims that CBD is helping people sleep better, feel better, look better, or be an all-around better human? If so, is that in the form of CBD oil, tinctures, lotions, or should we vape it? But wait — isn’t vaping bad for you?

Relax. We’ve got you covered. Herewith, the real scoop on CBD. (Buyer beware: Abbreviations ensue.)

Common Questions & Answers

Endocannabinoids are molecules produced by the body to maintain homeostasis — stability — in response to changes in the environment. The endocannabinoid system interacts with all of the major systems and organs in the body to enable and restore optimal functioning.

The word “cannabinoid” usually refers to a chemical found in the cannabis (marijuana or hemp) plant. “Endo,” in this context, refers to substances produced inside the body. Endocannabinoids are, in effect, the body’s own source of cannabis-like substances.

CBD and THC are plant cannabinoids, which operate much as endocannabinoids do, by attaching to certain receptors on the outsides of cells and altering the behavior of those cells or the bodily systems they are a part of.

Cannabinoids and endocannabinoids can affect pain perception, memory, mood, appetite, and many other bodily systems. The endocannabinoid system regulates the release of other neurotransmitters — that’s how it maintains homeostasis — and helps the body heal from any damage it sustains. Plant cannabinoids can similarly enhance feelings of well-being, but they can have undesirable side effects as well, particularly in young people.

Research suggests that endocannabinoids can be boosted by certain foods, such as those containing essential fatty acids, chocolate, herbs, spices, and teas, as well as by stress-reducing activities.

CBD: The Good, the Bad, and the Confusing

Before we get too much into the, er, weeds, it’s important to understand what CBD is and where it comes from.

Cannabis refers to a group of three varieties of marijuana plants with psychoactive properties: Cannabis sativa, Cannabis indica, and Cannabis ruderalis.

Cannabis contains more than 400 compounds, known as cannabinoids (pronounced keh-NAB-eh-noyd). The most well-known and researched are cannabidiol (CBD), and delta-9-tetrahydrocannabidiol (THC). Other lesser known components — THCA, CBN, CBC, and CBG — play different roles and have different effects in the body. (See our CBD glossary for details.)

The component in cannabis that is linked to its intoxicating effects (in other words, the “high,”) is THC. Conversely, CBD won’t get you high. Depending on your goals, this is either a good or a bad thing.

“Hemp” (which incidentally, is considered part of the CBD family) refers to non-intoxicating varieties that are high fiber or high seed-yielding and often used for rope, clothing, or sails. (Cocktail party fact: “The word ‘canvas’ comes from ‘cannabis,’ as it was made from cannabis fiber varietals,” says Will Kleidon, the CEO of Ojai Energetics in Ojai, California..)

In the United States, the legal definition of hemp is any cannabis plant whose delta-9 THC is below 0.3 percent.

What’s the Endocannabinoid System and How Does It Work?

The endocannabinoid system (ECS) is a biological system first described in the 1990s, and it plays a big role in brain, endocrine, and immune function. Its main role, however, is to maintain homeostasis, the internal biological balancing mechanism of the brain and body.

Two main elements of the system are endocannabinoid receptors, classified as CB1 and CB2. The body makes its own cannabinoids, known as endocannabinoids, that can act upon these receptors. But other varieties of cannabinoids, such as CBD, can interact with them, too.

What Are Cannabinoid Receptors?

Cannabinoid receptors are laced throughout the body, brain, and nerves.

  • Cannabinoid 1 (CB1) Receptors Most of these are in the central nervous system, especially neurons (nerve cells) in the brain.
  • Cannabinoid 2 (CB2) Receptors These are located mainly on immune cells but are also found in the central nervous system.

Both receptor types are activated by cannabinoids, which can be generated naturally inside the body (known as endocannabinoids) or can be introduced through a form of cannabis.

What’s the ‘Entourage Effect’?

The entourage effect refers to a theory that the whole is more effective than each part — or that the various compounds of the cannabis plant work best synergistically.

“It’s the theory that the cannabinoids, flavonoids, terpenes, and fatty acids all work together like an orchestra, in which all the instruments complement each other so you get the maximum effect of the plant,” says the cannabis researcher Monica Taing, PharmD. “CBD by itself can be a pain reliever, and THC can be a pain reliever by itself, but when combined, they work better for pain relief. That’s the entourage or ensemble effect.”

Now that that’s out of the way, let’s get into the nitty-gritty.

What Are the Legal Implications of Using CBD?

The legality of CBD is confusing.

In 2018, the Agriculture Improvement Act of 2018 (aka that year’s Farm Bill), legalized CBD derived from hemp — with the important caveat that it could only contain 0.3 percent of THC by dry weight, to be grown legally. This type of CBD is legal in 47 U.S. states with some restrictions, but totally illegal in Idaho, South Dakota, and Mississippi. Plants with more than 0.3 percent of THC are considered marijuana, which is legal for recreational use in 19 states, Washington, DC, and Guam.

Despite state laws legalizing the sale of cannabis for recreational or medicinal use, the Drug Enforcement Administration (DEA) (PDF) still classifies it as a Schedule 1 drug: “substances or chemicals [that] are defined as drugs with no currently accepted medical use and a high potential for abuse.” So, while marijuana is illegal on a federal level, states have different laws regarding marijuana and CBD.

Only one cannabis-derived drug product has been FDA approved: cannabidiol sold under the brand name Epidiolex, which contains a purified form of high-dose CBD to treat a rare, hard-to-treat form of epilepsy in children ages 1 and up.

How Do I Find Safe CBD Products? How Do I Know What I’m Getting?

Short answer: You often don’t.

The situation is not unlike that of dietary supplements, except for in the case of supplements, the FDA has defined a very clear set of restrictions — and the Federal Trade Commission, strict reinforcement of health claims. While the FDA has sent warning letters to certain companies selling CBD products, many products slip under the radar. In addition, state and Federal CBD regulations are at odds, so oversight can be difficult. What’s more, every state where medical or recreational marijuana is legal has its own testing rules and regulations, so something that passes muster in Massachusetts might not in California.

People often buy their products online or at the local drugstore or gas station, meaning that they often don’t know what they’re getting.

“Some CBD products don’t contain CBD, but they contain THC and heavy metals, so we need strong regulations,” says Dr. Taing. Indeed, as of May 21, 2022, poison control centers have managed 2,652 cases related to CBD, per the American Association of Poison Control Centers.

Some people have failed drug tests because they’ve unwittingly taken THC that was in a product that was supposed to contain only CBD. A study published in the Journal of the American Medical Association (JAMA) in November 2017 found that 21 percent of CBD products derived from hemp and sold online contained THC, even though THC wasn’t listed on the packaging.

A more recent study in JAMA Psychiatry showed that even a high-quality, high-potency cannabidiol product labeled as carrying as much as tenfold less than the legal limits of THC permissible under law might still result in positive urine drug tests.

Findings from another study, published June 2022 in the Journal of Cannabis Research, showed that of the 80 products evaluated, 37 contained CBD concentrations that were at least 10 percent higher or lower than the concentration listed on the label: 12 products contained less than 90 of what was listed, while 25 products contained more than 110 percent.

Even more worrisome, a study published in January 2019 in Forensic Science International examined nine liquids that were advertised as 100 percent natural CBD extract and found they contained potentially problematic compounds. One contained dextromethorphan, which is used in over-the-counter cough medication and is considered addictive when abused. Four others had a synthetic cannabinoid that can cause, among other things, anxiety, psychosis, and even death.

“As with any other product you would ingest, you have to be smart,” says Jahan Marcu, PhD, the editor in chief of the American Journal of Endocannabinoid Medicine, and the cofounder and chief science officer at the International Research Center on Cannabis and Mental Health.

What’s more, he says, every product should have a certificate of analysis, or COA — a document generated by a laboratory certifying its legitimacy and also listing the ingredients.

The Mayo Clinic uses the following checklist to identify high-quality products, as described in a 2019 issue of Mayo Clinic Proceedings:

  1. Does it meet the following quality standards? These include Current Good Manufacturing Practices (CGMP) certification from the FDA; European Union (EU), Australian (AUS), or Canadian (CFIA) organic certification; National Science Foundation (NSF) International certification.
  2. Does the company have an independent adverse event reporting program?
  3. Is the product certified organic or eco-farmed?
  4. Have their products been laboratory tested by batch to confirm tetrahydrocannabinol levels below 0.3 percent and no pesticides or heavy metals?

For more information, Project CBD, Certified Kind, Clean Green, and WeedMaps offer information on dispensaries, cannabis products, and brands.

Does It Matter if the CBD Is Organic?

In theory, yes, because without an organic label, there’s a potential for ingesting pesticides and chemical fertilizers. If you have a COA, then you’ll know what’s in the product.

But here’s the rub: Organic products are regulated by the U.S. Department of Agriculture (USDA), which is a federal agency. Since cannabis is considered a Schedule 1 drug, technically, medical cannabis couldn’t be designated as “organic,” unless it’s made from hemp.

In May 2018, Palmetto Grow became the first company to have USDA Organic certification for hemp flower and seed. Since then, other organic growers have joined the market. You can find a list of some of the best organic CBD products from EcoWatch and The Honest Consumer.

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