CBD Oil For Arthritis


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CBD or cannabidiol topical formulations, are derived from the natural cannabis hemp plants. Find out the 5 best CBD oil for arthritis 2022. If you have chronic arthritis pain, you may have been tempted to try cannabidiol as a treatment, or you may have tried it already. But is there any evidence that it works? Studies are finally addressing this question, and the results are just starting to come in.

Best CBD Oils For Arthritis & Joint Pain: Top 5 CBD Brands Reviewed 2022

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Arthritis [1] is known as the chronic or acute inflammation of the joints. The arthritis symptoms include stiffness of the joint, pain and nerve damage, reduced range of mobility, and deformity of the joint. One must note that joint pain, also called arthralgia, may or may that doesn’t associate with arthritis. The most common form of arthritis is degenerative arthritis or osteoarthritis, which is non-inflammatory.

Inflammatory arthritis can typically associate with autoimmune diseases such as myositis, systemic lupus erythematosus, inflammatory bowel disease, and Sjogren syndrome. Approximately 30% of the American population demonstrates arthritis on imaging, with the onset increasing as a person grows older.

While pain management medications [2] are widely used for alleviation of osteoarthritis pain, these are associated with several adverse effects. Cannabidiol [3] or CBD is derived from the Cannabis sativa plant. It is a psychoactive compound, which has potential pain management properties. CBD does not prevent hyperalgesia, rather it reduces mechanical hyperalgesia and has anti-inflammatory and analgesic properties. Cannabis or hemp seed oil as well as hemp-derived CBD products that we can use both orally and topically.

5 Best CBD Oils for Arthritis & Joint Pain In 2022

    – Editor’s Choice – Best CBD Oils for Anxiety and Depression – Best Value – Best Pure CBD – Best THC-Free

Features Of The Best CBD Oils for Arthritis & Joint Pain

The CBDfx formula for muscle and joint pain comprises broad-spectrum CBD along with caffeine and white willow bark. The formulation also contains menthol so as to provide a cooling effect in the area of joint and muscle pain. CBDfx vegan and cruelty-free formulation make the product usable by both vegan and non-vegan individuals. The CBDfx formula for muscle and joint pain is available in different strengths including 500 mg, 3000 mg, and 1000 mg formulations.

The use of natural pain relievers in topical CBD products including white willow bark, caffeine, and broad-spectrum CBD make the product safe and free of any adverse effects. The topical formulation provides temporary pain relief and does not leave a greasy effect after topical application. This formulation provides long-lasting relief from joint and muscle pain as well as alleviates discomfort.

  • Derived from organically grown hemp plants
  • Relieve arthritis pain naturally
  • Vegan

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Spruce CBD
  • Full-spectrum CBD, provides an entourage effect
  • CBD strain with a unique terpene profile
  • No dilutes and the most potent CBD oil

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  • Made from certified non-GMO organic hemp grown in Colorado
  • Full-spectrum cannabinoids including terpenes
  • CO2 extraction

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Joy Organics
  • USDA-certified organic ingredients
  • Broad-spectrum and full-spectrum CBD oil
  • Contains phytonutrients

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Medterra CBD Oil
  • Does not contain THC
  • CBG and CBD in a 1:1 ratio
  • Organically grown industrial hemp

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5 Best CBD Oil for Arthritis Reviewed 2022


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The CBDfx muscle and joint pain relief formulation is enriched with naturally derived pain-relieving ingredients which provide long-term pain relief. It has a solvent-free and cruelty-free composition and absorbs rapidly into the skin, providing prompt pain-relieving effects.

  • Vegan and cruelty-free formulation
  • CBD oil derived from organically grown hemp plants
  • Natural pain reliever with minimal side effects
  • A wide range of products to choose from
  • Residual solvent may be found in CBDfx formulation, which should have been removed during the CO2 extraction process

The CBDfx muscle and joint pain relief formulation absorbs into the skin rapidly and acts on deeper tissues including muscles and joints. Unlike other pain relief topical formulations, it does not leave a greasy after-effect or an unpleasant smell. The ingredient profile is a blend of menthol, white willow bark, broad-spectrum CBD, and caffeine.

White willow bark contains salicylic acid, the same active ingredient used in aspirin. Caffeine treats pain by blocking the activity of adenosine receptors which involve in pain signaling. The icy and cooling effect of menthol eliminates discomfort and soothes muscle and joint pain.

The formulation provides long-lasting pain relief which enhances the performance of the individual, which is otherwise compromised owing to pain, discomfort, and reduced range of mobility in arthritis. The pain relief formulation has significantly reduced the need for consuming aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) and the occurrence of associated side effects.

Spruce CBD

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The Spruce CBD oil is made with completely natural ingredients with minimal side effects. The products are available in a range of higher potencies and comprise lab-grade organic ingredients.

  • CBD oil contains full-spectrum CBD and high-grade pure CBD made with 100% natural ingredients
  • The superior extraction method eliminates the solvent residues and provides an increased CBD dosage in the product
  • The product is available in different potencies
  • Less potent CBD oils are not available

The Spruce CBD oils are worth every penny, say a majority of Spruce CBD oil customers. The free shipping option and prompt delivery of the product make it customers’ favorite. Compared to other competitor brands, the Spruce CBD oil is affordable with a fair and suitable cost. The third-party lab testing ensures the optimal quality of the product and confirms that the product is devoid of heavy metals, biotoxins, and pesticides.

The users report alleviation of chronic pain and inflammation, the symptoms of arthritis. Spruce CBD oil is a natural alternative to pain management prescription medications. The product comes with a dropper which makes topical application of the product an easy process. The vegan and cruelty-free formulation are the reasons why Spruce CBD oil is highly popular among its customers.

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The CBDPure oil is made of certified non-GMO organic standard hemp which is grown in Washington and Colorado. CBDPure oil comprises the most powerful CBD packed with numerous health benefits.

  • The CBDPure CBD formulation comprises 100% organic and cleanest industrial hemp from Colorado, making the CBD oil safe, effective, and high-quality.
  • The third-party lab testing of the CBD organic hemp oil confirms that the product does not contain herbicides, pesticides, and fertilizers.
  • The supercritical CO2 extraction process removes residual solvents and impurities as well as preserves phytonutrients from the cannabis plant.
  • Lack a wide range of CBD oil favors to choose from

Farmers grow the hemp at local family farms in Washington and Colorado, where, the farmers and manufacturers ensure that the hemp is 100% organic and does not contain any artificial or synthetic ingredients. They test each batch for purity and quality to ensure that it meets the standards. The third-party testing of their oil includes CBD testing to verify the concentration and quality of CBD, pesticide testing, heavy metal testing, microbiological screening, and residual solvent testing.

Plus, they are a trustworthy name among healthcare professionals and the general public which is health-conscious. They provide high-quality CBD oil and other CBD products at an affordable price, unlike other brands that cost a fortune. The 90-day money-back guarantee provides the customers with a complete refund if they don’t feel satisfied with the result. This reflects the confidence of the brand in the safety, quality, and efficacy of their oil.

Joy Organics

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Joy Organics CBD oil contains naturally-derived USDA certified ingredients. The brand offers a wide range of full-spectrum and broad-spectrum CBD products which contain terpenes, tetrahydrocannabinol (THC), cannabinol (CBN), and cannabigerol (CBG).

  • Uses USDA-certified organic ingredients to formulate CBD oil and other CBD products
  • The quality, safety, and composition of the products are backed by third-party testing
  • The 30-day satisfaction guarantee for all the products is also a plus point.
  • The majority of the products contain broad-spectrum hemp extract, whereas, only a few options contain full-spectrum CBD.

We know Joy Organics for its transparency when it comes to updating the website for both internal and third-party testing reports. The third-party reports are available for every raw batch and finished product. The QR code on each product allows the users to access these reports as well. The faculty at Joy Organics is compliant with the regulations of Current Good Manufacturing Practices (CGMPs).

Joy Organics provides a wide range of products at a reasonable price. It provides discounts to teachers, medical personnel, veterans, first responders, and individuals with low socioeconomic backgrounds. The potency of topical formulations ranges from 250 to 500 mg, which is relatively lesser than other alternate brands.

Medterra CBD Oil

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The Medterra CBD oil is made of the finest CBD isolate and is an effective product for relieving pain and stress. The safety and efficacy of CBD oil are confirmed by third-party lab testing.

  • Medterra CBD oil has an A+ Better Business Bureau rating with fewer complaints regarding the product on the BBB website
  • Medical experts are part of the Medterra manufacturing to formulate and develop the products
  • As compared to the alternate brands, Medterra CBD oil is affordable for everyone while the brand maintains its quality throughout
  • Unlike other brands, Medterra does not offer discounts to its customers except for rewards programs and discounts associated with subscriptions.

Medterra has an A+ rating on the BBB website and is certified by the US Hemp Authority for using the highest quality CBD in its products. The medical advisory board at Medterra comprises veterinarians and medical experts who contribute to the formulation of Medterra CBD products and also conduct research to support the claims. Similar to other CBD brands, Medterra also provides third-party lab testing results to its users. The finest CBD isolate used in Medterra CBD oil and other products relieves arthritis symptoms.

CBD Benefits for Arthritis

CBD [4] has anti-inflammatory properties, which make it an integral component of natural anti-inflammatory treatment and management regimens for arthritis and joint pain. It increases the levels of calcium inside the cells as well as reduces the levels of interleukin IL-6, IL-8, and matrix metalloproteinase MMP-3 in inflammatory arthritis.

Is CBD Oil Good for Arthritis?

Arthritis is a debilitating illness that must associate with chronic pain, swelling, and reduced mobility in the affected joint. While pain management medications are useful for short-term reduction of pain, these medications are accompanied by several adverse effects. CBD oil has anti-inflammatory and analgesic properties which makes it a suitable natural alternative to pain-relieving medications.

Types of Arthritis

There are up to 100 types of arthritis. Some may be inflammatory, non-inflammatory, or autoimmune. An osteoarthritis is a form of arthritis, characterized by the wear and tear of joints. Osteoarthritis involves the degeneration of the cartilage followed by bone damage at the joint. Rheumatoid arthritis is an autoimmune form of arthritis that involves the degeneration of cartilage. The autoimmune and inflammatory responses trigger in response to environmental stimuli. Septic arthritis is another form of arthritis which characterize by the inflammatory response to a bacterial infection. The most common organism responsible for septic arthritis is Staphylococcus aureus. Gout is another form of arthritis with associating with needle-shaped crystals of monosodium urate.

How CBD Oil Helps with Arthritis

The topical application of CBD oil or ingestion of oral CBD capsules and CBD gummies has numerous health benefits including alleviation of pain in arthritis and management of pain-related behaviors. The transdermal cannabinoid reduces inflammation by decreasing the production and release of pro-inflammatory cytokines such as IL-6, IL-8, and MMP-3. This ultimately relieves pain for longer periods, eliminates discomfort, and improves the quality of life.

The CBDfx formulation, CBD cream, for muscle and joint pain also contains caffeine and white willow bark which alleviate pain by blocking the activity of the adenosine receptors.

Does CBD Have Side Effects?

Commonly reported side effects of CBD include tiredness, appetite changes, weight changes, and diarrhea. CBD can also interact with other medications.

How To Choose The Best CBD Oils for Joint Pain

The selection of CBD oil depends on the personal preference of the consumer, however, certain products cater to certain health problems. We also determine the selection of CBD oil by the tolerable and desirable strength of the CBD oil.

While some people opt for CBD oil with a greater CBD concentration, others settle for CBD oils with lesser CBD content. Before buying CBD oil and using it, one must consult a physician about any possible drug interactions.

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How To Use a CBD Oil for Joint Pain

While you can ingest CBD, you can also apply CBD oil and other formulations topically to the affected joint area. MCT (medium-chain triglycerides) carrier oil facilitates the absorption of CBD products into the skin.

The amount of the product depends on the area and the number of joints affected. One shall take the suitable concentration of CBD oil and massage it onto the skin to alleviate pain and discomfort. You can see the best results when you apply the product three to four times to the affected area each day.

Frequently Asked Questions (FAQs)

Yes. Consistent and appropriate use of CBD oil alleviates the pain and discomfort in arthritis patients.

For the topical application of CBD oil, one shall take the amount suitable for the affected area and massage it thoroughly on the skin.

The best time to use CBD oil for arthritis is when one experiences joint pain and discomfort.

CBD oil provides long-term relief from joint pain and discomfort. One shall use the oil consistently for the best results.

CBD oil is a safe and natural alternative to pain management medications for joint pain in arthritis. It is well tolerable among the users and has very few mild side effects such as tiredness.

The topical application of CBD oil to the affected area provides rapid pain relief. The results can be observed 10 to 20 minutes after the application of the product.

The strength of CBD product or the concentration of CBD in that product depends on the preference and tolerance of the individual. While some people prefer low-strength CBD products, others opt for high potency CBD oil.

The intoxicating effects depend on the amount of THC in the CBD oil. With trace amounts of THC, the product is well-tolerable and does not cause intoxication.

+ 9 sources

MIDSS has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We work mostly with peer-reviewed studies to ensure accurate information. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

  1. Shayan Senthelal, Li, J., Goyal, A. and Thomas, M.A. (2022). Arthritis. [online] Nih.gov. Available at: https://www.ncbi.nlm.nih.gov/books/NBK518992/ [Accessed 2 Jul. 2022].
  2. ‌Queremel, D.A. and Davis, D.D. (2022). Pain Management Medications. [online] Nih.gov. Available at: https://www.ncbi.nlm.nih.gov/books/NBK560692/ [Accessed 2 Jul. 2022].
  3. Argueta, D.A., Ventura, C.M., Kiven, S., Sagi, V. and Gupta, K. (2020). A Balanced Approach for Cannabidiol Use in Chronic Pain. Frontiers in Pharmacology, [online] 11. doi:10.3389/fphar.2020.00561.
  4. Lowin, T., Tingting, R., Zurmahr, J., Classen, T., Schneider, M. and Pongratz, G. (2020). Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts. Cell Death & Disease, [online] 11(8). doi:10.1038/s41419-020-02892-1.
  5. Senthelal S, Li J, Goyal A, et al. Arthritis. [Updated 2022 May 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from:https://www.ncbi.nlm.nih.gov/books/NBK518992/
  6. Queremel Milani DA, Davis DD. Pain Management Medications. [Updated 2022 Feb 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from:https://www.ncbi.nlm.nih.gov/books/NBK560692/
  7. Argueta, D. A., Ventura, C. M., Kiven, S., Sagi, V., & Gupta, K. (2020). A Balanced Approach for Cannabidiol Use in Chronic Pain. Frontiers in pharmacology, 11, 561.https://doi.org/10.3389/fphar.2020.00561
  8. Lowin, T., Tingting, R., Zurmahr, J., Classen, T., Schneider, M., & Pongratz, G. (2020). Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts. Cell death & disease, 11(8), 714.https://doi.org/10.1038/s41419-020-02892-1
  9. Iffland, K., & Grotenhermen, F. (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and cannabinoid research, 2(1), 139–154.https://doi.org/10.1089/can.2016.0034


Rick is a Final Year Medical Student. Passionate about medicine, fitness and personal growth, he is always ready to challenge himself to accomplish tasks and especially spread correct medical information to people. Rick is a long-term medical writer for several sites. With more than 5 years of experience in medical writing, he has completed 200+ projects with private and business clients.


Drew is a retired ENT doctor who now lives in the Southeastern US. He was a member of the American Academy of Otolaryngology and a Fellow of the American College of Surgeons. He has a bachelor’s degree in Biology and Psychology and an MD degree. He completed his internship in General Surgery and Residency in Otolaryngology-Head and Neck Surgery and practiced for almost 30 years in all aspects of ENT, including a specialization in disorders of the ear and skull base. Drew is passionate about communicating his clinical experiences and making his knowledge more accessible to the general public by medical writing.

Does CBD help with arthritis pain?

If you have chronic arthritis pain, you may be wondering about cannabidiol (CBD) as a treatment. CBD, along with delta-9-tetrahydrocannabinol (THC) and other chemicals, is found in marijuana. But unlike THC, CBD is not “psychoactive” — that is, it does not cause the intoxication or high associated with marijuana use.

There’s a good chance you’ve tried it already: according to a Gallup poll in August of 2019, about 14% of Americans report using CBD products, and the number one reason is pain. The Arthritis Foundation conducted its own poll and found that 29% reported current use of CBD (mostly in liquid or topical form), and nearly 80% of respondents were either using it, had used it in the past, or were considering it. Of those using it, most reported improvement in physical function, sleep, and well-being; of note, a minority reported improvement in pain or stiffness.

Perhaps you’ve been tempted to try it. After all, most types of arthritis are not cured by other treatments, and CBD is considered a less addictive option than opiates. Or maybe it’s the marketing that recommends CBD products for everything from arthritis to anxiety to seizures. The ads are pretty hard to miss. (Now here’s a coincidence: as I was writing this, my email preview pane displayed a message that seemed to jump off the screen: CBD Has Helped Millions!! Try It Free Today!)

What’s the evidence it works? And what do experts recommend? Until recently, there’s been little research and even less guidance for people (or their doctors) interested in CBD products that are now increasingly legal and widely promoted.

But now, there is.

A word about arthritis pain

It’s worth emphasizing that there are more than 100 types of arthritis, and while pain is a cardinal feature of all of them, these conditions do not all act alike. And what works for one may not work for another. Treatment is aimed at reducing pain and stiffness and maintaining function for all types of arthritis. But for certain conditions, such as rheumatoid arthritis, conventional prescription medications are highly recommended, because these drugs help prevent permanent joint damage and worsening disability.

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In addition, individuals experience pain and respond to treatment in different ways. As a result, it’s highly unlikely that there is a single CBD-containing product that works for all people with all types of arthritis.

What’s the evidence that CBD is effective for chronic arthritis pain?

While there are laboratory studies suggesting CBD might be a promising approach, and animal studies showing anti-inflammatory and pain-relieving effects, well-designed studies demonstrating compelling evidence that CBD is safe and effective for chronic arthritis pain in humans do not exist. A randomized trial of topical CBD for osteoarthritis of the knee has been published, but in abstract form only (meaning it’s a preliminary report that summarizes the trial and has not been thoroughly vetted yet); the trial lasted only 12 weeks, and results were mixed at best. One of the largest reviews examined the health effects of cannabis and CBD, and concluded that there is “substantial evidence that cannabis is an effective treatment for chronic pain in adults.” But there was no specific conclusion regarding CBD, presumably because definitive studies were not available.

Of course, there is anecdotal evidence and testimonials galore, including reports of dramatic improvement by people who tried CBD in its various forms (including capsule, liquid, topical, and spray) for their pain. But we are still waiting for well-designed, scientifically valid, and rigorous clinical trials (such as this one in progress) that are so badly needed to answer the question of just how helpful CBD may be to people with chronic arthritis pain.

Are there downsides to CBD treatment?

As with any treatment, there can be downsides. CBD is generally considered safe; however, it can still cause lightheadedness, sleepiness, dry mouth, and rarely, liver problems. There may be uncertainty about the potency or purity of CBD products (since they are not regulated as prescription medications are), and CBD can interact with other medications. For pregnant women, concern has been raised about a possible link between inhaled cannabis and lower-birthweight babies; it’s not clear if this applies to CBD. Some pain specialists have concerns that CBD may upset the body’s natural system of pain regulation, leading to tolerance (so that higher doses are needed for the same effect), though the potential for addiction is generally considered to be low.

There is one definite downside: cost. Prices range widely but CBD products aren’t inexpensive, and depending on dose, frequency, and formulation, the cost can be considerable — I found one brand that was $120/month, and health insurance does not usually cover it.

Are there guidelines about the use of CBD for chronic arthritis pain?

Until recently, little guidance has been available for people with arthritis pain who were interested in CBD treatment. Depending on availability and interest, patients and their doctors had to decide on their own whether CBD was a reasonable option in each specific case. To a large degree that’s still true, but some guidelines have been published. Here’s one set of guidelines for people pursuing treatment with CBD that I find quite reasonable (based on recommendations from the Arthritis Foundation and a recent commentary published in the medical journal Arthritis Care & Research):


  • If considering a CBD product, choose one that has been independently tested for purity, potency, and safety — for example, look for one that has received a “Good Manufacturing Practices” (GMP) certification.
  • CBD should be one part of an overall pain management plan that includes nonmedication options (such as exercise) and psychological support.
  • Choose an oral treatment (rather than inhaled products) and start with a low dose taken in the evening.
  • Establish initial goals of treatment within a realistic period of time — for example, a reduction in knee pain that allows you to walk around the block within two weeks of starting treatment; later, if improved, the goals can be adjusted.
  • Tell your doctor(s) about your planned and current CBD treatment; monitor your pain and adjust medications with your medical providers, rather than with nonmedical practitioners (such as those selling CBD products).


  • Don’t make CBD your first choice for pain relief; it is more appropriate to consider it if other treatments have not been effective enough.
  • Don’t have nonmedical practitioners (such as those selling CBD products) managing your chronic pain; pain management should be between you and your healthcare team, even if it includes CBD.
  • For people with rheumatoid arthritis or related conditions, do not stop prescribed medications that may be protecting your joints from future damage; discuss any changes to your medication regimen with your doctor.

The bottom line

If you’re interested in CBD treatment for chronic arthritis pain or if you’re already taking it, review the pros, cons, and latest news with your healthcare providers, and together you can decide on a reasonable treatment plan. Depending on the type of arthritis you have, it may be quite important to continue your conventional, prescribed medications even if you pursue additional relief with CBD products.

We may not have all the evidence we’d like, but if CBD can safely improve your symptoms, it may be worth considering.

Follow me on Twitter @RobShmerling

About the Author

Robert H. Shmerling, MD , Senior Faculty Editor, Harvard Health Publishing

Dr. Robert H. Shmerling is the former clinical chief of the division of rheumatology at Beth Israel Deaconess Medical Center (BIDMC), and is a current member of the corresponding faculty in medicine at Harvard Medical School. … See Full Bio


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