CBD Entourage Oil


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According to the entourage effect, CBD may be more beneficial in the presence of other hemp-derived compounds, rather than by itself. The entourage effect describes unique synergy achieved by all cannabinoids and terpenes in the cannabis plant. What does the entourage effect mean for CBD users? This article will provide you with everything you need to know about the whole-plant concept. An Explanation of One of the Most Powerful Medicinal Discoveries: The Entourage Effect Full-spectrum is one of the most popular buzzwords in the CBD industry, but what does it mean? It appears front and center on many CBD products, including ours, but why? What is the Entourage Effect and why is it so important?

The Entourage Effect & CBD Oil – Is It A Game-Changer?

Thanks to a phenomenon known as the entourage effect, CBD oil and other CBD products appear to be more effective when in the presence of other natural hemp compounds, rather than by themselves.

If true, this would suggest that full-spectrum CBD products may be more beneficial compared to isolate or even broad-spectrum products. Full-spectrum products include a complete range of terpenes, cannabinoids, and other compounds found in hemp. Broad-spectrum products are similar, minus the presence of THC.

Isolate products are pure CBD and contain no additional cannabinoids. As we continue to learn more about the entourage effect and its potential impact on humans using CBD products, we explore what we know thus far below.

Read on to find out more.

What Is The Entourage Effect?

In basic terms, the entourage effect helps maximize the beneficial effects of CBD oil. It occurs when hundreds of different compounds in hemp interact with each other simultaneously to produce a synergistic physiological effect.

In 1998, doctors Raphael Mechoulam and Shimon Ben-Shabat were the first to suggest that the endocannabinoid system (ECS) demonstrated an ‘entourage effect.’ According to the Israeli researchers, various inactive metabolites and related molecules appeared to boost the activity of primary endogenous cannabinoids in the human body (namely 2-AG and anandamide).

In simpler terms, the entourage effect suggests that CBD is not solely responsible for the beneficial effects it produces in the body. The presence of other cannabinoids – such as CBN and CBDV – as well as terpenes like myrcene and beta-caryophyllene, appear to “amplify” the activity of CBD and its influence on various physiological systems.

Many suggest that terpenes, in particular, have a far more impactful presence in hemp extract than previously imagined. Terpenes are genuinely fascinating, not least because we’re still finding out how much they can help us. You can find terpenes everywhere, from the skin of citrus fruits to the essential oils squeezed from plant seeds.

Aside from smelling great, terpenes appear to help CBD function in the most efficient way possible. Think of it like a car; you could hypothetically drive down the road with a flat tire, a busted windshield, and a leaking radiator, but it would be a lot more efficient — and effective — if all those parts were functioning properly and working together.

What Does CBD Have To Do With The Entourage Effect?

Some people are incorrectly referring to this phenomenon as the “CBD entourage effect.” Indeed, CBD plays a tremendous role in the synergistic effects produced by dozens of hemp compounds working together and interacting with one another. However, it is inaccurate to label it as the most important part of the process.

In fact, no single hemp component should be labeled as the most important aspect of the entourage effect. All the “working internal parts” of hemp play a role. Even if a single phytochemical component is missing, the cumulative effect may be diminished.

That said, and going back to the car analogy, some hemp components do likely play more influential roles than others. That is, doing what the car is designed to do – which is get down the road as efficiently as possible.

In this analogy, CBD would almost certainly be the engine of the car; without it, the car’s not going anywhere. So, while it’s incorrect to label the entourage effect as the “CBD entourage effect,” there’s no denying that CBD plays a massive role in the whole synergistic process.

An “Entourage” of CBD Products…

So what’s a potential CBD user to make of all this information? It seems that with each passing day, there’s a greater entourage of CBD oil products out there on the market to choose from. How do you know which one’s best for you?

Well, it goes without saying that any quality CBD oil product needs to start out with quality hemp. At Premium Jane, we source all of our hemp from farms right here in the USA. We also only use non-GMO.

Why? Because we believe the safety and effectiveness of the end product can only ever be as high as the quality of the starting plant material. In other words, only the purest, highest quality plants can produce the purest, highest quality CBD oil products. It’s really as simple as that.

What Else Should I Know About CBD Oil & The Entourage Effect?

To take full advantage of the entourage effect, CBD oil would need to be consumed in the form of a full-spectrum hemp extract (FSE). In the most basic sense, full-spectrum products contain a complete range of hemp’s natural phytochemicals. This includes small amounts of THC at levels of 0.3% or less.

Of course, FSE products are not the best option for every single user out there. For example, for folks that want to avoid consuming THC altogether, a broad-spectrum product or even a CBD isolate product would be a better option.

Broad-spectrum CBD products are very similar to full-spectrum products. The only difference is that broad-spectrum products are 100% THC-free. CBD isolate products, of course, contain CBD and nothing else.

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At Premium Jane, we understand that the needs of our customers vary. This is why we offer two major types of CBD products: full-spectrum and CBD isolate. If you’re looking for the market’s most expertly-crafted range of authentic hemp-derived products, there’s really no better option than the USA-made Premium Jane range.

The Bottom Line On The Entourage Effect & CBD Products

According to the phenomenon of the entourage effect, CBD is most effective when in the presence of other natural hemp phytocompounds. In other words, it appears that cannabinoids (including CBD) are influenced by the presence of other compounds. This includes terpenes, flavonoids, and possibly even nutritional components like hemp-derived omega acids.

Both full and broad-spectrum CBD products contain a variety of hemp compounds. Hemp CBD isolates, on the other hand, contain nothing except for the isolated CBD compound. Depending on a user’s personal needs, one type of CBD product may be preferred over another.

Those looking to benefit from the entourage effect should opt for a premium full or broad-spectrum CBD product. But those who want to avoid consuming any quantity of THC, may find that a CBD isolate product is the preferred option.

CBD Entourage Effect: What Is It & How It Works with Other Cannabinoids

The entourage effect is one of the most intriguing discoveries in recent times when it comes to cannabis plants and their compounds. Proponents of the entourage effect claim that extracts produced from the whole cannabis plant increase the efficacy of its health benefits — something that would be unachievable with isolated compounds.

Scientists have contradictory views on this concept. There are clear indications that full-spectrum cannabis extracts are more effective in certain cases than their isolated counterparts. The advocates of isolating specific compounds and standardizing dosages aren’t so positive about these findings, claiming that attributing the entourage effect to all situations is a far-reaching generalization.

A full-spectrum product in the world of cannabis includes cannabinoids — even traces of THC — terpenes, and other compounds. There are also broad-spectrum extracts and isolates. The broad-spectrum is like a “light” version of full-spectrum because it contains all the aforementioned substances except for THC. Isolates, in turn, refers to pure cannabinoids that have been separated from the remaining constituents of cannabis. These are flavorless and odorless products that are sold in powders or infused into different items.

In this article, we’ll focus specifically on the entourage effect; this will be the most detailed yet to-the-point guide you’ll ever read, so even when you’re done with the text, save it for later and share it with friends to increase their awareness about different CBD spectra.

What Makes Cannabinoids and Terpenes So Special?

Cannabinoids and terpenes are the active ingredients of cannabis that work synergistically to amplify the health benefits of each other. Cannabis researchers call it “the entourage effect.”

The debate has usually revolved around THC vs CBD, and comparing which one is better. But in fact, we should look at them as complementary compounds that can help you get the most out of your cannabis use.

Believe it or not, there’s a whole lot going on in the plant on a molecular level.

But how does one decode the term “entourage effect?” What is the role of the other 113 cannabinoids and 200 terpenes?

Find your answers in the next section.

What is the Entourage Effect in CBD?

In very simple terms, the entourage effect helps maximize the health benefits of CBD oil. It occurs when all the compounds within the cannabis plant interact with our bodies, producing stronger effects than they would if a person took them in isolation. These stronger effects are referred to as a “synergy.”

The entourage effect was first mentioned by two scientists in 1998 — Raphael Mechoulam and Shimon Ben-Shabat. They suggested that the endocannabinoid system (ECS) manifested “the entourage effect.” (1) According to the authors of the study, various “inactive” compounds and related molecules enhanced the activity of the major endogenous cannabinoids: 2-AG and anandamide. Mechoulam and Ben-Shabat said their discovery made it clear why botanical medications were often more effective than synthetic isolates.

For CBD oil users, it means that CBD isn’t the only compound responsible for the health benefits you experience. If you feel stronger relief from the stress of physical discomfort using a full-spectrum CBD oil, this may be caused by the synergistic effects provided by other cannabinoids, such as CBD, CBDV, CBG, CBC, or CBN, and terpenes such as beta-caryophyllene, limonene, myrcene, or linalool.

While CBD is a powerful compound on its own, it needs a team of supporters to develop its full potential.

Terpenes are fascinating molecules, and we’re going to devote an entire section to them, but before we make it there, let’s take a look at the most well-known entourage effect between CBD and THC.

THC & CBD: The Most Well-Known Cannabis Entourage Effect

One of the first observed and most cited entourage effects is the relationship between CBD and THC.

While THC, the cannabinoid that gets you high, binds directly to the CB1 cannabinoid receptors in the brain, CBD uses different mechanisms to manifest its effects. When you take these two compounds together, CBD reduces THC’s psychotic potential by blocking the sites of the CB1 receptors to which THC tries to bind. As a result, you feel less high than you would if you consumed THC alone.

The evidence supporting CBD’s ability to help take the edge off THC is piling up. In the 1980s, the Food and Drug Administration (FDA), approved a synthetic form of THC known as Marinol. While the medication did a decent job of increasing patients’ appetite, it also had side effects such as paranoia. Another FDA-approved drug, Sativex, contains both CBD and THC in a 1:1 ratio, so patients can tolerate it without getting too stoned.

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Once you understand the interaction between CBD, THC, and the CB1 receptor, you should get a general idea of how the entourage effect works.

THC is the agonist of this receptor, meaning it works like a key that unlocks the receptor’s lock. CBD isn’t a direct agonist of the CB1 receptor, but it competes with THC for its space. As mentioned, taking these two compounds together leaves fewer receptors for THC to activate. In this scenario, the potential side-effects of THC, such as anxiety and paranoia, are modulated.

Adie Wilson-Poe, a professor at Washington University (St. Louis) says that CBD uses a minimum of 14 different mechanisms of action in the central nervous system alone. Aside from that, it has over 65 molecular targets. CBD acts through a myriad of pathways, so it’s hard to link its health benefits solely to CB1 occupation.

Now, when you take full-spectrum CBD oil, there are a lot more compounds entering your body. Using full-spectrum products activates legions of beneficial molecules at the same time.

Benefits of THC-Only Products

Please note that we cannot make any health claims regarding cannabis compounds. We always encourage you to do your own research and explore the world of cannabinoids and terpenes. Below we only share information about the potential benefits of THC-only and CBD-only products.fg

The benefits of THC include:

  • Deep relaxation
  • Relief from stress
  • Reduced discomfort and stiffness
  • Regulation of the sleep cycle
  • Modulation of the gut microbiome
  • Improved appetite

THC effects usually reach their peak when you consume an edible. When you eat a cannabis brownie, for example, THC gets metabolized in the liver, transforming into 11-hydroxy-THC. This metabolite is five times stronger than THC. So, when you smoke cannabis and take 10 mg of THC, it enters your lungs and goes to the bloodstream through the lung tissue. A 10 mg THC edible translates to 50 mg of THC when it comes to its potency.

Benefits of CBD-Only Products

CBD has very different effects from THC. The most vivid example is the lack of intoxication. It is the compound of choice for those who don’t tolerate THC well or are afraid of failing a drug test. Cannabidiol is also great for general supplementation because it supports the proper functioning of the endocannabinoid system.

CBD is mostly used to relieve:

  • Stress
  • Sleep deprivation
  • Psychosis
  • Physical discomfort
  • Tiredness
  • Endocannabinoid deficiencies

CBD also has a strong affinity with the immune system, regulating communication between immune cells and improving its performance.

What Happens When You Start to Use Whole-Plant Products?

The modulation of the psychoactive effects of THC is a significant benefit of the entourage effect, but the whole-plant concept is about more than that. Full-spectrum products can improve the overall efficacy of cannabinoids. The main reason why this is a new discovery is the lack of research regarding the health benefits of cannabis due to its prohibition. The minor cannabinoids, as well as terpenes, have many positive effects of their own, but it’s difficult to gauge the efficacy of certain entourage effects with different ratios of these compounds.

From our perspective, it’s rather a matter of the entourage effect making everything better rather than isolates being less effective — as far as preliminary research shows.

Evidence of the Entourage Effect

There’s a lot of science to support the higher efficacy of full-spectrum CBD. In 2011, Ethan Russo, one of the most esteemed cannabis researchers, published an important study in the British Journal of Pharmacology (2). In the study, Russo wrote that cannabinoids and terpenes produce synergistic effects that translate to better therapeutic effects.

Russo also conducted a more recent study published in the journal Frontiers in Plant Science in 2019 (3). He reviewed multiple studies that investigated the case for the Entourage effect. Russo concluded that there is strong evidence to suggest that the phytochemical factory in cannabis is more beneficial for humans than isolates.

In contrast, a study by Santiago et al., published in Biorxiv in 2019, claimed that there is no such thing as the entourage effect (4). The authors of the study analyzed the responses of cells transfected with human cannabinoid receptors (CB1 and CB2) in the presence of THC and a few selected terpenes.

The authors found that the receptors were not altered by any of these compounds, whether they coexisted together or were used in separation. However, the authors also admitted limitations to their research. The main concern was the fact that the team only focused on a single CB1 and CB2 pathway.

What Are Terpenes?

Most people think about fragrances and flavors in herbs when they hear the word “terpenes.”

However, the research conducted over the last few years have shown that terpenes are potent therapeutic molecules. That’s because they are responsible for starting the entourage effect in the cannabis plant.

Terpenes are volatile aromatic substances that evaporate easily and provide plants, fruits, vegetables, and spices with their unique aromas. The more aromatic the plant, the more terpenes are in it.

If you’ve ever wondered why cannabis strains smell differently but still have some characteristics similar to other plants — the answer is “terpenes.”

So far, we know about 200 terpenes in cannabis, but only a few of them occur in concentrations large enough to be worth mentioning.

Terpenes can be broken down into three groups:

  • Monoterpenes
  • Diterpenes
  • Sesquiterpenes

Whether a specific terpene falls into one of these categories depends on the number of repeating units of a 5 carbon molecule known as isoprene, the structural marker of all terpenes.

10 Most Commonly Found Terpenes in Cannabis

As mentioned earlier, only a few terpenes are found in amounts substantial enough to mention them in this text:

Here are the 10 most commonly found terpenes in the cannabis plant:

  1. Myrcene
  2. Linalool
  3. Pinene
  4. Limonene
  5. Beta-Caryophyllene
  6. Humulene
  7. Eucalyptol
  8. Delta-3-Carene
  9. Borneol
  10. Terpineol
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Health Benefits of Terpenes

It is true that terpenes influence the aromas of plants, but there’s a growing body of evidence that they have a plethora of health benefits — especially when consumed along with cannabinoids such as CBD.

The list of potential health benefits of terpenes include:

  • Reduced stress
  • Appetite control
  • Relief from physical discomfort
  • Cognitive boost
  • Better blood circulation
  • Modulation of nausea and vomiting
  • Protection of healthy cells
  • Sedation

Needless to say, these effects are stronger when put together in a cannabis extract such as full-spectrum CBD oil.

Final Thoughts on the Entourage Effect

The entourage effect has garnered a lot of attention recently. If this concept is true for all cannabis extracts, it may change the way people use hemp and marijuana-based products forever. However, the existence of this phenomenon doesn’t necessarily mean that broad-spectrum CBD or CBD isolate is inferior to full-spectrum products. There are cases where the entourage effect isn’t the desired effect.

Nevertheless, the concept that cannabinoids and terpenes are more powerful together than on their own is an intriguing one. In an interesting video, Dr. Sean McAllister evaluates the effects of THC and CBD on tumor growth. He suggests that using the two cannabinoids on cancerous cells in the lab leads to faster death of malignant cells while protecting the healthy ones.

The real challenge faced by scientists is to find out how we can possibly leverage the entourage effect by manipulating the ratios of cannabinoids and terpenes. When we get a deeper understanding of this phenomenon, we could adjust different forms of CBD to specific needs. Now that’s what we call personalized science!

An Explanation of One of the Most Powerful Medicinal Discoveries: The Entourage Effect

Full-spectrum is one of the most popular buzzwords in the CBD industry, but what does it mean? It appears front and center on many CBD products, including ours, but why? What is the so-called Entourage Effect and why is it so important? This blog post examines the scientific benefits of full-spectrum CBD products and the Entourage Effect.

Defining Full-Spectrum

A full-spectrum product contains CBD along with all of the other minor cannabinoids and terpenes naturally produced by the hemp plant. That is, it contains the full-spectrum of hemp compounds. Fitting name, right? This is in contrast to broad-spectrum and isolate products. Broad-spectrum products contain CBD and all minor cannabinoids except THC. Isolate products contain only CBD. Full-spectrum oils are the truest representation of the hemp plant, and the most therapeutic. This is where understanding the Entourage Effect comes into play.

The Entourage Effect: 1 + 1 = 3

The Entourage Effect is a term for the synergistic benefit derived from all compounds found in the hemp plant. CBD is just one beneficial cannabinoid, but paired with THC, minor cannabinoids, terpenes, and other hemp compounds, a greater therapeutic benefit is achieved than any one compound in isolation.CBD, THC, minor cannabinoids, and even some terpenes all interact with your Endocannabinoid System (ECS). Your ECS regulates a wide range of biological processes (sleep, appetite, memory, immune function, pain response to name a few). By pairing CBD with other compounds that interact with the ECS, it increases the effectiveness of CBD.Dr. Ethan Russo is a leader in medicinal cannabis research and has shared multiple papers supporting the Entourage Effect. Many users have experienced little to no benefit from CBD isolate products, but have been helped greatly by full-spectrum products due to the Entourage Effect.

Why is CBD with THC Better?

Full-spectrum CBD oil containing THC and other cannabinoids is far superior to CBD oils containing just CBD. THC is typically the most abundant compound (outside of CBD) in CBD oil. THC contributes greatly to the therapeutic effects of CBD, even in low concentrations that don’t lead to intoxication (e.g. 0.3% for hemp products). This is due to the Entourage Effect.All BATCH products, except for our Muscle Gel, contain full-spectrum CBD oil. Using our in-house HPLC testing instrument, we’ve identified and quantified seven well-known cannabinoids found in our extracts: CBDV, CBDA, CBG, CBD, d9-THC, d8-THC, and CBC. Additionally, there are hundreds of lesser-known, and less abundant, cannabinoids that we don’t have the abilities to quantify. All of these cannabinoids further contribute to the healing powers of full-spectrum CBD products.

What Role Do Terpenes Play in the Entourage Effect?

Terpenes are a class of organic compounds that also contribute to the Entourage Effect. They are aromatic in nature, giving plants their scents. For example, pinene gives pine trees their distinctive smell. Limonene contributes to citrus fruits’ odor. These compounds are also found in the hemp plant. We all know how smelly the hemp plant can be! Some terpenes (e.g. beta-caryophyllene) interact directly with the Endocannabinoid System and can contribute to the Entourage Effect and the healing ability of CBD.All of our CBD oil contains naturally occurring terpenes found in the hemp plant. In addition to this, we supplement our products with terpene isolates to dial up or down desired effects depending on the product application. This is how we formulate different effect-based blends like Clarity, Dream, Soothe, and Calm.

All CBD is Not Equal

The high price of CBD may motivate some customers to search for the cheapest available option. While we’re all for frugality, we also have to caution our customers. Make sure the CBD you are purchasing is indeed full-spectrum and backed up with lab results (preferably from a trusted third-party lab). Look for cannabinoids besides CBD on potency lab reports. Isolate products are typically cheaper, but lack the true power of the Entourage Effect. We highly recommend full-spectrum products for the highest therapeutic benefit.

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