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5 Buspirone Uses, Side Effects, Dosage + Natural Options

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Note that each number in parentheses [1, 2, 3, etc.] is a clickable link to peer-reviewed scientific studies. A plus sign next to the number “[1+, 2+, etc. ]” means that the information is found within the full scientific study rather than the abstract.

Buspirone is a prescription medication indicated primarily for anxiety but may also be used “off-label” for depression and other mental disorders. Read on to learn the uses and side effects of buspirone + natural complementary approaches to anxiety.

Disclaimer: This post is not a recommendation or endorsement for buspirone. This medication is only FDA-approved for the treatment of certain specific medical disorders, and can only be taken by prescription and with oversight from a licensed medical professional. We have written this post for informational purposes only, and our goal is solely to inform people about the science behind buspirone’s effects, mechanisms, and current medical uses.

What is Buspirone?

Buspirone is an anti-anxiety medication (anxiolytic) that is sold under the brand name Buspar. It is chemically and pharmacologically distinct from other anti-anxiety drugs such as benzodiazepines and offers reduced anxiety without physical dependence or withdrawal symptoms [R, R].

Buspirone is most commonly used for generalized anxiety disorder but is also prescribed occasionally for anxiety related to other brain-related disorders such as depression, attention deficit disorder, social phobia, Parkinson’s disease and Alzheimer’s [R, R].

Mechanism of Action

The mechanism of action of buspirone is not fully understood. It is known that buspirone binds to serotonin (5-HT1A) receptors and partially mimics the action of serotonin. Serotonin is a chemical in the brain that promotes feelings of well-being and happiness [R, R].

Buspirone is also able to partially block the action of some dopamine receptors (DRD2) [R, R].

When buspirone is broken down by the body, one of the major byproducts called 1-PP becomes quite concentrated in the blood. 1-PP can block the activity of a receptor that epinephrine/adrenaline activates (α2-adrenergic), which could account for some of the anti-depressant effects of buspirone [R, R, R, R].

When taken by mouth (20 mg) it is rapidly absorbed and reaches its peak concentration within the blood in less than an hour. It takes 2.5 hours for half of the initial dose to be removed from the body (half-life). However, like most anti-anxiety medications, it may take 3-4 weeks until you start to feel relief from symptoms [R, R].

Approved Medical Uses

1) Anxiety

Buspirone treatment is more effective than placebo in treating and maintaining stability for generalized anxiety disorder (GAD) based on a ten-week trial in 125 patients [R].

GAD is persistent, uncontrollable worry that requires professional therapy or medication to be resolved [R, R].

Buspirone is as effective as benzodiazepines, such as diazepam or lorazepam for treating generalized anxiety. This was shown in a study of 367 menstruating female patients, and 2 studies with 84 adults [R, R, R].

It is equal to or better (after 2 and 4 weeks) than sertraline (an SSRI) for GAD, based on a study of 46 people [R].

Based on the above results, the FDA has officially approved buspirone for the treatment of generalized anxiety.

Off-Label Uses

Occasionally, doctors will prescribe drugs like buspirone to help treat conditions that fall outside of the official uses approved by the FDA – also known as “off-label” drug use. Usually, this is done because there is actually decent evidence that the drug may help, although not enough to get full FDA approval [R].

However, keep in mind that the decision to use medications in this way can only be made by a licensed medical professional.

2) Depression

Buspirone is more effective for treating major depressive disorder than placebo, based on a meta-analysis looking at the results of 15 randomized controlled trials with a total of 2,469 patients [R].

Two large studies performed in 300 adults for 8 weeks with both major depression and moderate anxiety resulted in significant improvement in symptoms for a majority of treated patients [R, R].

Taking buspirone for 8 weeks improved major depression in 61% of 177 elderly patients (double-blind randomized controlled trial) [R].

A randomized study of 286 adults being treated for depression with citalopram, found that augmentation with 60 mg/day buspirone resulted in a 30% remission rate based on the Hamilton Rating Scale for Depression [R].

Buspirone increases cortisol secretion (via 5HT1A), which may improve depressive symptoms [R].

3) Substance Abuse

The use of buspirone to help overcome substance abuse has had somewhat disappointing results, as conflicting data have been published for substance abuse of many types.

Buspirone was useful in helping high anxiety patients stop smoking in a study with 101 people. Participants that were considered to be low anxiety did not experience any benefit from taking buspirone [R].

However, it did not help 35 crack cocaine users (60 mg/d) in their addiction [R].

The effects of buspirone treatment on marijuana dependence have been conflicting. One study of 50 adults found it helped, while it didn’t with another study of 175 people [R, R].

Buspirone did not help methamphetamine use in 8 participants [R].

In primates, buspirone was found to be helpful in reducing nicotine and cocaine addiction [R].

Other Potential Uses

Buspirone has also been studied for other health conditions. However, keep in mind that the evidence supporting these potential applications is still only preliminary, and a lot more additional research will be needed before any of these applications are approved. Therefore, take all of the information below with a grain of salt.

4) Sexual Risk-Taking in Cocaine Users

There is an association between cocaine use and sexually transmitted diseases that are attributed to an increase in sexual desire and a decrease in self-control when using cocaine. Buspirone improves impulse control in rats and reduced the reinforcing effects of cocaine in preclinical trials [R, R].

Nine cocaine users were treated with 30 mg/day of buspirone for 3 days (repeated measures, inpatient protocol). Buspirone did not interact negatively with cocaine and users were found to be more likely to use a condom [R].

However, a placebo-controlled study of 11 cocaine users found no effect of buspirone on impulse control, but only a slower reaction time at the very highest dose tested (30mg) [R].

Chronic administration of buspirone has some beneficial effect on impulse control in both rodents and non-human primates [R, R, R].

5) Symptoms of Developmental Disorders

In a study of 166 children with autism, ages 2 to 6, small doses of buspirone (2.5 mg) helped alleviate repetitive behaviors [R].

In 40 kids with autism, low doses of buspirone in combination with an antipsychotic (risperidone) resulted in significantly decreased irritability [R].

A case study reported decreased hyperactivity and an increased ability to complete performance tasks in a child with autism [R].

Buspirone Side Effects & Safety

A meta-analysis 289 patients found that the most common side effects are dizziness, headache, and nausea [R].

Patients generally do not experience drowsiness, weakness, fatigue or depression as is common with other anti-anxiety medications [R, R, R].

There are some anecdotal reports of Buspirone causing weight gain, but there are no clinical reports that back this claim. A pilot study on 6 schizophrenic patients actually observed weight reduction for patients switching to buspirone from olanzapine or risperidone (which are known to cause weight gain) [R].

The following are other potential side effects reported on various sites, but they are not found in the scientific literature:

  • nervousness/restlessness
  • blurred vision
  • dry mouth
  • upset stomach
  • stuffy nose
  • sore throat
  • ringing in the ears

Drug Interactions

Drug interactions can be dangerous and, in rare cases, even life-threatening. Always consult your doctor before taking any drug and let them know about all drugs and supplements you are using or considering.

A study in 10 healthy volunteers found that taking buspirone in combination with grapefruit juice significantly increases the blood concentration of the drug, and should be avoided when taking this prescription medication [R].

There is a reported case study of serotonin syndrome in an individual taking buspirone and linezolid concomitantly. Consult your doctor before combining buspirone with other anti-anxiety or anti-depression medications [R].

A study performed in 24 healthy men found that alcohol (0.8 g/kg) and buspirone had little additive effect on intoxication and in some cases, buspirone seemed to reverse the effects of alcohol [R].

Another study in 12 young males found no interaction between buspirone and alcohol. However, alcohol affects everyone differently, so it’s extremely important to take caution when combining alcohol and prescription medications [R].

Contraindications

  • Buspirone hypersensitivity.
  • MAO-inhibitors (antidepressants) within 14 days due to increased risk of serotonin syndrome and/or elevated blood pressure.

Pregnancy and Breastfeeding Considerations

Buspirone has a category B risk in pregnancy. In general, there are no definitive studies that have shown buspirone to be a risk to the fetus. However, caution is always advised if you are going to take the medication while pregnant, and the benefits of taking the medication should be weighed versus any potential risk to the fetus.

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Please speak to your doctor or a qualified healthcare professional. It is not known if buspirone is transferred to breast milk, but it is advised to not take it if you are breastfeeding [R].

Buspirone Forms and Dosage

The below doses may not apply to you personally. If your doctor suggests using buspirone, work with them to find the optimal dosage according to your health condition and other factors.

Buspirone is available in 5 mg, 7.5 mg, 10 mg, 15 mg, and 30 mg tablets, and is commonly taken at 15 mg/day for treatment of anxiety (divided into 2 or 3 doses), but the dosage is dependent on indication and clinical trials have found it is well tolerated up to 90 mg/day [R, R, R, R].

Overdose/Toxicity

Buspirone is generally thought to have a more ideal side-effect profile than benzodiazepines. There is only a single report of buspirone overdose causing a seizure in a human, although there are additional animal model reports of this happening [R].

Buspirone vs. Xanax

Buspirone improves anxiety by acting on serotonin receptors in the brain, while Xanax alters the effect of GABA, another neurotransmitter. Buspirone does not have sedative, muscle relaxant or anti-convulsive effects that benzodiazepines such as Xanax have. Additionally, Buspirone has a much smaller potential for abuse and minimal withdrawal symptoms [R].

Genetics

CYP enzymes are responsible for breaking down or metabolizing drugs that enter the body. Buspirone is metabolized by CYP3A4, so mutations in this enzyme could change how buspirone is processed and how it affects you. Specifically, the T variant of the rs35599367 SNP is associated with decreased enzymatic activity in the liver, which could lead to higher drug levels in the bloodstream [R].

Natural Complementary Approaches

In most cases, complementary approaches cannot permanently resolve a diagnosed anxiety disorder. If you have one, make sure to precisely follow your doctor’s recommendations. That being said, supplements and lifestyle changes discussed below may improve the effectiveness of conventional treatment options.

1) Exercise

Exercise has been shown in numerous studies to be effective for reducing anxiety. Aerobic exercise, such as running, biking or hiking, is most effective. Similar to buspirone, exercise reduces anxiety by increasing beneficial neurotransmitters such as serotonin, dopamine, norepinephrine, and endorphins [R, R, R, R, R, R].

2) Probiotics

A large proportion of people with anxiety have also been found to have GI disorders and evidence for a link between the gut microbiota and brain function is quickly growing. More specifically, the gut microbiota is being shown to play an important role in Serotonin production [R, R, R, R].

Like buspirone, increasing the health of your gut-flora by supplementing with probiotics can improve serotonin transmission and help reduce anxiety. The following strains have been specifically shown to improve psychological health:

3) 5-Hydroxytryptophan (5-HTP)

5-Hydroxytryptophan (5-HTP) is an over the counter supplement that is a precursor to serotonin. Similarly to the way that buspirone treats anxiety by boosting serotonin activity, supplementing with 5-HTP has been shown to reduce anxiety and panic attacks in humans [R, R].

4) Cannabidiol (CBD)

CBD is a component of hemp that is non-psychoactive and has many proven health benefits. CBD has been shown to reduce anxiety in both healthy patients and those that have been clinically diagnosed with social anxiety disorder. CBD interacts with the same serotonin receptors (5-HT1A) as buspirone [R, R, R, R].

Keep in mind that CBD may not be legal in your country. Check with your doctor if CBD would be a legal and potentially effective addition to treatment.

5) Ashwagandha

Ashwagandha is an Indian herb that helps to restore hormonal imbalance and improve immune function. It has been shown in humans to help stabilize mood fluctuations and has proven anti-anxiety effects in animal models [R, R, R, R].

Based on a study in mice, the anti-anxiety effects of ashwagandha could be due to a resulting increase in both GABA and serotonin [R].

6) Lemon Balm

Lemon balm is an herb commonly consumed as a tea that has been shown in several small human trials to reduce anxiety. A study performed in rats suggests that lemon balm may increase the activity of serotonin, similar to the effect of buspirone [R, R, R, R, R].

7 ) Lavender

Lavender is a flowering plant with a pleasant smell that is often associated with calmness and sleep. Silexan is an oil derived from lavender that can be taken by mouth. Clinical trials in humans have shown that Silexan can reduce anxiety in patients with post traumatic stress and anxiety disorders [R, R, R].

Animal studies have shown that similarly to buspirone, the serotonin system plays an important role in the anti-anxiety effects of lavender oil [R, R].

CBD and other medications: Proceed with caution

Products containing cannabidiol (CBD) seem to be all the rage these days, promising relief from a wide range of maladies, from insomnia and hot flashes to chronic pain and seizures. Some of these claims have merit to them, while some of them are just hype. But it won’t hurt to try, right? Well, not so fast. CBD is a biologically active compound, and as such, it may also have unintended consequences. These include known side effects of CBD, but also unintended interactions with supplements, herbal products, and over-the-counter (OTC) and prescription medications.

Doubling up on side effects

While generally considered safe, CBD may cause drowsiness, lightheadedness, nausea, diarrhea, dry mouth, and, in rare instances, damage to the liver. Taking CBD with other medications that have similar side effects may increase the risk of unwanted symptoms or toxicity. In other words, taking CBD at the same time with OTC or prescription medications and substances that cause sleepiness, such as opioids, benzodiazepines (such as Xanax or Ativan), antipsychotics, antidepressants, antihistamines (such as Benadryl), or alcohol may lead to increased sleepiness, fatigue, and possibly accidental falls and accidents when driving. Increased sedation and tiredness may also happen when using certain herbal supplements, such as kava, melatonin, and St. John’s wort. Taking CBD with stimulants (such as Adderall) may lead to decreased appetite, while taking it with the diabetes drug metformin or certain heartburn drugs (such as Prilosec) may increase the risk of diarrhea.

CBD can alter the effects of other drugs

Many drugs are broken down by enzymes in the liver, and CBD may compete for or interfere with these enzymes, leading to too much or not enough of the drug in the body, called altered concentration. The altered concentration, in turn, may lead to the medication not working, or an increased risk of side effects. Such drug interactions are usually hard to predict but can cause unpleasant and sometimes serious problems.

Researchers from Penn State College of Medicine evaluated existing information on five prescription CBD and delta-9-tetrahydrocannabinol (THC) cannabinoid medications: antinausea medications used during cancer treatment (Marinol, Syndros, Cesamet); a medication used primarily for muscle spasms in multiple sclerosis (Sativex, which is not currently available in the US, but available in other countries); and an antiseizure medication (Epidiolex). Overall, the researchers identified 139 medications that may be affected by cannabinoids. This list was further narrowed to 57 medications, for which altered concentration can be dangerous. The list contains a variety of drugs from heart medications to antibiotics, although not all the drugs on the list may be affected by CBD-only products (some are only affected by THC). Potentially serious drug interactions with CBD included

  • a common blood thinner, warfarin
  • a heart rhythm medication, amiodarone
  • a thyroid medication, levothyroxine
  • several medications for seizure, including clobazam, lamotrigine, and valproate.

The researchers further warned that while the list may be used as a starting point to identify potential drug interactions with marijuana or CBD oil, plant-derived cannabinoid products may deliver highly variable cannabinoid concentrations (unlike the FDA-regulated prescription cannabinoid medications previously mentioned), and may contain many other compounds that can increase the risk of unintended drug interactions.

Does the form of CBD matter?

Absolutely. Inhaled CBD gets into the blood the fastest, reaching high concentration within 30 minutes and increasing the risk of acute side effects. Edibles require longer time to absorb and are less likely to produce a high concentration peak, although they may eventually reach high enough levels to cause an issue or interact with other medications. Topical formulations, such as creams and lotions, may not absorb and get into the blood in sufficient amount to interact with other medications, although there is very little information on how much of CBD gets into the blood eventually. All of this is further complicated by the fact that none of these products are regulated or checked for purity, concentration, or safety.

The bottom line: Talk to your doctor or pharmacist if using or considering CBD

CBD has the potential to interact with many other products, including over-the-counter medications, herbal products, and prescription medications. Some medications should never be taken with CBD; the use of other medications may need to be modified or reduced to prevent serious issues. The consequences of drug interactions also depend on many other factors, including the dose of CBD, the dose of another medication, and a person’s underlying health condition. Older adults are more susceptible to drug interactions because they often take multiple medications, and because of age-related physiological changes that affect how our bodies process medications.

People considering or taking CBD products should always mention their use to their doctor, particularly if they are taking other medications or have underlying medical conditions, such as liver disease, kidney disease, epilepsy, heart issues, a weakened immune system, or are on medications that can weaken the immune system (such as cancer medications). A pharmacist is a great resource to help you learn about a potential interaction with a supplement, an herbal product (many of which have their own drug interactions), or an over-the-counter or prescription medication. Don’t assume that just because something is natural, it is safe and trying it won’t hurt. It very well might.

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Boom Finally, the starry sky rays that swallowed the Cbd Oil Australia how long is weed in blood reddit nebula were destroyed by Ye Fan.

She didn t expect that Qi Hong s strength was so strong that it could make the anti shock power of the Ancestral Emperor Mirror invalid.

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Instead of fighting with Ye Fan to the death, it is better to keep the strength and save it for the next God Monument Festival.

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At the beginning, at the God Monument Festival, the demons invaded, and Ye Fan fought against the demon generals alone.

Of course, he understood that it was Old Wei s action that had such an effect.

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But wanting to enter the crack is not so simple.

Through Ye Fan s body, the two most mysterious beings were connected.

Well said, let s keep going Qi Linglong controlled the starry sky spirit boat and rushed towards the inside of the tomb.

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If it wasn t for his carelessness, then this Dao Enlightenment Flower should have belonged to him.

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The old prince was also shocked, buspirone and cbd interaction his heart trembled.

Boom It was like some kind of terrifying beast, awakening from his body, sweeping across the sky, sweeping across the sky.

At this moment, Qi Linglong wiped the blood on the corner of his mouth and said, Senior, you are buspirone and cbd interaction indeed unparalleled But as long as I m still standing, you can never hurt Ye Fan sleep gummies review Qi Linglong, you are so stubborn and want to protect this stinky boy Nan Yutian was difference between hemp cbd oil and marijuana cbd oil furious.

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This is the top ancient divine beast in the world of immortality, and many people cannot see it once in their entire lives.

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Zi la, zi la, zi will i test positive for thc if i take cbd oil la Endless blood colored lightning flashed over the blood sparrow s feathers.

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Although there has always been Cbd Oil Australia how long is weed in blood reddit LatestInWorld buspirone and cbd interaction such a saying in the world of immortality, no one has LatestInWorld buspirone and cbd interaction seen the appearance of the Protoss, and no one has been able to stix vape pen cbd oil catridge obtain the magical treasures of the Protoss Ye Fan, there are treasures of the Protoss, buspirone and cbd interaction as expected.

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Boom, boom, boom The powerful blade light instantly swept the entire ancient battlefield, causing Cbd Ground Coffee buspirone and cbd interaction many monks with low cultivation bases to be turned into ashes.

Afterwards, the content in the Shidian of the Heaven s Path was actually reflected in the sky, forming words like colored jade.

It lives in the turbulent flow of time and space all year round, and has an extremely keen sense of danger.

the power is infinite. Kill Donghuang Cbd Ground Coffee buspirone and cbd interaction saturated canary Aotian roared, the golden dragon spear roared, and a golden holy dragon hovered above his head, fighting against the power of heaven and earth.

Shu Swish Swish At the same time, dozens of magical buspirone and cbd interaction treasures appeared all over his body, each of which was of the highest quality and could be integrated with his own cultivation.

Dressed in buspirone and cbd interaction a red dress, she is where to buy cbd oil in boise trader joes bright and moving and dazzling.

Shhh She pointed her finger on the top of her eyebrows, and suddenly a stream of white light was launched towards the surrounding, and then condensed does cbd oil make you calm and launched towards the bottom.

You are in an ominous position, and you have brought great harm to the Big Dipper galaxy Hmph, you actually conquered the god monument and caused the opening of the demon channel.

It was the treasure of the Taiyi Holy buspirone and cbd interaction How To Use Cbd Thc Tincture Land.

Okay Since the buspirone and cbd interaction princess is so confident, then I m welcome Qi Hong s eyes narrowed, and he already had a plan in his heart.

Okay, hurry up and fight Horse Cbd Ground Coffee buspirone and cbd interaction The old prince walked to Shang Bin s position.

Even if there buspirone and cbd interaction are, it is only one or two sporadic, and they have to hide their traces and dare not expose them, otherwise they will attract the siege of the human race powerhouses.

, it s ridiculous, it s impossible to suppress me with this move Zheng Qifeng seemed to how long is weed in blood reddit Customers Experience see through his thoughts, his figure moved instantly, constantly flashing in the space, and at the same time, there actually appeared on the field.

what happened to my body outside At this moment, he finally understood.

call After an unknown amount of time, Qi Linglong let out a long breath, and she felt her body recover greatly.

Boom Suddenly, there was a change in the enchantment of the monument, and a strong pressure dropped, constantly destroying Ye Fan buspirone and cbd interaction how long is weed in blood reddit s body, which made the loss of his cultivation more rapid, and it seemed that everything was lost.

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